diff --git a/meson.build b/meson.build
index cecdbc3aa7..af282af19c 100644
--- a/meson.build
+++ b/meson.build
@@ -1729,6 +1729,7 @@ if conf.get('BPF_FRAMEWORK') == 1
                 'riscv32' : ['-D__riscv', '-D__riscv_xlen=32'],
                 'riscv64' : ['-D__riscv', '-D__riscv_xlen=64'],
                 'x86'     : ['-D__i386__'],
+                's390x'   : ['-D__s390__', '-D__s390x__'],
 
                 # For arm, assume hardware fp is available.
                 'arm'     : ['-D__arm__', '-D__ARM_PCS_VFP'],