diff --git a/docs/HACKING.md b/docs/HACKING.md
index 9e5313e07a..a74d0468e5 100644
--- a/docs/HACKING.md
+++ b/docs/HACKING.md
@@ -140,6 +140,11 @@ enabled that are suitable when hacking on systemd (such as internal
 documentation consistency checks). Those are not useful when compiling for
 distribution and can be disabled by setting `-Dmode=release`.
 
+## Sanitizers in mkosi
+
+See [Testing systemd using sanitizers](TESTING_WITH_SANITIZERS.md) for more information
+on how to build with sanitizers enabled in mkosi.
+
 ## Fuzzers
 
 systemd includes fuzzers in `src/fuzz/` that use libFuzzer and are automatically
diff --git a/docs/TESTING_WITH_SANITIZERS.md b/docs/TESTING_WITH_SANITIZERS.md
index 4f965c9617..642e1f19c9 100644
--- a/docs/TESTING_WITH_SANITIZERS.md
+++ b/docs/TESTING_WITH_SANITIZERS.md
@@ -13,6 +13,22 @@ This is mostly done automagically by various CI systems for each PR, but you may
 want to do it locally as well. The process slightly varies depending on the
 compiler you want to use and which part of the test suite you want to run.
 
+## mkosi
+
+To build with sanitizers in mkosi, create a file 20-local.conf in mkosi.default.d/ and add the following
+contents:
+
+```
+[Content]
+Environment=SANITIZERS=address,undefined
+```
+
+The value of `SANITIZERS` is passed directly to meson's `b_sanitize` option, See
+https://mesonbuild.com/Builtin-options.html#base-options for the format expected by the option. Currently,
+only the sanitizers supported by gcc can be used, which are `address` and `undefined`.
+
+Note that this will only work with a recent version of mkosi (>= 14 or by running mkosi directly from source).
+
 ## gcc
 gcc compiles in sanitizer libraries dynamically by default, so you need to get
 the shared libraries first - on Fedora these are shipped as a separate packages
diff --git a/mkosi.build b/mkosi.build
index 2be8fdbda1..27e5b1c65c 100755
--- a/mkosi.build
+++ b/mkosi.build
@@ -5,6 +5,9 @@ set -e
 # This is a build script for OS image generation using mkosi (https://github.com/systemd/mkosi).
 # Simply invoke "mkosi" in the project directory to build an OS image.
 
+ASAN_OPTIONS=strict_string_checks=1:detect_stack_use_after_return=1:check_initialization_order=1:strict_init_order=1:disable_coredump=0:use_madv_dontdump=1
+UBSAN_OPTIONS=print_stacktrace=1:print_summary=1:halt_on_error=1
+
 # On Fedora "ld" is (unfortunately — if you ask me) managed via
 # "alternatives". Since we'd like to support building images in environments
 # with only /usr/ around (e.g. mkosi's UsrOnly=1 option), we have the problem
@@ -61,7 +64,8 @@ if [ ! -f "$BUILDDIR"/build.ninja ] ; then
                 -D man=false \
                 -D translations=false \
                 -D version-tag="${VERSION_TAG}" \
-                -D mode=developer
+                -D mode=developer \
+                -D b_sanitize="${SANITIZERS:-none}"
 fi
 
 cd "$BUILDDIR"
@@ -71,7 +75,15 @@ if [ "$WITH_TESTS" = 1 ] ; then
                 getent group $id >/dev/null || groupadd -g $id testgroup$id
         done
 
-        ninja test
+        if [ -n "$SANITIZERS" ]; then
+                export ASAN_OPTIONS="$ASAN_OPTIONS"
+                export UBSAN_OPTIONS="$UBSAN_OPTIONS"
+                TIMEOUT_MULTIPLIER=3
+        else
+                TIMEOUT_MULTIPLIER=1
+        fi
+
+        meson test --timeout-multiplier=$TIMEOUT_MULTIPLIER
 fi
 cd "$SRCDIR"
 
@@ -120,3 +132,42 @@ if [ -n "$CI_BUILD" ]; then
         cp -v "$SRCDIR/test/mkosi-check-and-shutdown.sh" "$DESTDIR/usr/lib/systemd/mkosi-check-and-shutdown.sh"
         chmod +x "$DESTDIR/usr/lib/systemd/mkosi-check-and-shutdown.sh"
 fi
+
+if [ -n "$SANITIZERS" ]; then
+        LD_PRELOAD=$(ldd $BUILDDIR/systemd | grep libasan.so | awk '{print $3}')
+
+        mkdir -p "$DESTDIR/etc/systemd/system.conf.d"
+
+        cat > "$DESTDIR/etc/systemd/system.conf.d/10-asan.conf" <<EOF
+[Manager]
+ManagerEnvironment=ASAN_OPTIONS=$ASAN_OPTIONS\\
+                   UBSAN_OPTIONS=$UBSAN_OPTIONS\\
+                   LD_PRELOAD=$LD_PRELOAD
+DefaultEnvironment=ASAN_OPTIONS=$ASAN_OPTIONS\\
+                   UBSAN_OPTIONS=$UBSAN_OPTIONS\\
+                   LD_PRELOAD=$LD_PRELOAD
+EOF
+
+        # ASAN logs to stderr by default. However, journald's stderr is connected to /dev/null, so we lose
+        # all the ASAN logs. To rectify that, let's connect journald's stdout to the console so that any
+        # sanitizer failures appear directly on the user's console.
+        mkdir -p "$DESTDIR/etc/systemd/system/systemd-journald.service.d"
+
+        cat > "$DESTDIR/etc/systemd/system/systemd-journald.service.d/10-stdout-tty.conf" <<EOF
+[Service]
+StandardOutput=tty
+EOF
+
+        # Both systemd and util-linux's login call vhangup() on /dev/console which disconnects all users.
+        # This means systemd-journald can't log to /dev/console even if we configure `StandardOutput=tty`. As
+        # a workaround, we modify console-getty.service to disable systemd's vhangup() and disallow login
+        # from calling vhangup() so that journald's ASAN logs correctly end up in the console.
+
+        mkdir -p "$DESTDIR/etc/systemd/system/console-getty.service.d"
+
+        cat > "$DESTDIR/etc/systemd/system/console-getty.service.d/10-no-vhangup.conf" <<EOF
+[Service]
+TTYVHangup=no
+CapabilityBoundingSet=~CAP_SYS_TTY_CONFIG
+EOF
+fi
diff --git a/mkosi.default.d/10-systemd.conf b/mkosi.default.d/10-systemd.conf
index 08a03f489b..24b85ddd0b 100644
--- a/mkosi.default.d/10-systemd.conf
+++ b/mkosi.default.d/10-systemd.conf
@@ -6,6 +6,8 @@
 Format=gpt_btrfs
 Bootable=yes
 HostonlyInitrd=yes
+# Prevent ASAN warnings when building the image
+Environment=ASAN_OPTIONS=verify_asan_link_order=false
 
 [Packages]
 BuildDirectory=mkosi.builddir
@@ -16,6 +18,7 @@ SourceFileTransferFinal=copy-git-others
 [Host]
 QemuHeadless=yes
 NetworkVeth=yes
+QemuMem=2G
 
 [Validation]
 Password=
diff --git a/mkosi.default.d/centos_epel/10-mkosi.centos_epel b/mkosi.default.d/centos_epel/10-mkosi.centos_epel
index 42b3c11629..086fcdb555 100644
--- a/mkosi.default.d/centos_epel/10-mkosi.centos_epel
+++ b/mkosi.default.d/centos_epel/10-mkosi.centos_epel
@@ -78,6 +78,8 @@ Packages=
         e2fsprogs
         # xxd is provided by the vim-common package
         vim-common
+        libasan
+        libubsan
         # Required to run systemd-networkd-tests.py
         python3
         iproute
diff --git a/mkosi.default.d/debian/10-mkosi.debian b/mkosi.default.d/debian/10-mkosi.debian
index 44e8521d9a..9b77b5b832 100644
--- a/mkosi.default.d/debian/10-mkosi.debian
+++ b/mkosi.default.d/debian/10-mkosi.debian
@@ -74,6 +74,8 @@ Packages=
         nano
         strace
         xxd
+        # Provides libasan/libubsan
+        gcc
         # Required to run systemd-networkd-tests.py
         python3
         iproute2
diff --git a/mkosi.default.d/fedora/10-mkosi.fedora b/mkosi.default.d/fedora/10-mkosi.fedora
index a6b58c7589..0314a2faab 100644
--- a/mkosi.default.d/fedora/10-mkosi.fedora
+++ b/mkosi.default.d/fedora/10-mkosi.fedora
@@ -77,6 +77,9 @@ Packages=
         compsize
         # xxd is provided by the vim-common package
         vim-common
+        # Sanitizers
+        libasan
+        libubsan
         # Required to run systemd-networkd-tests.py
         python
         iproute
diff --git a/mkosi.default.d/opensuse/10-mkosi.opensuse b/mkosi.default.d/opensuse/10-mkosi.opensuse
index 53fe2f3c93..b1ca381759 100644
--- a/mkosi.default.d/opensuse/10-mkosi.opensuse
+++ b/mkosi.default.d/opensuse/10-mkosi.opensuse
@@ -75,3 +75,5 @@ Packages=
         util-linux
         # xxd is provided by the vim package
         vim
+        # Provides libasan/libubsan
+        gcc
diff --git a/mkosi.default.d/ubuntu/10-mkosi.ubuntu b/mkosi.default.d/ubuntu/10-mkosi.ubuntu
index 0a54547f87..dfb0ec0fd5 100644
--- a/mkosi.default.d/ubuntu/10-mkosi.ubuntu
+++ b/mkosi.default.d/ubuntu/10-mkosi.ubuntu
@@ -72,6 +72,8 @@ Packages=
         nano
         strace
         xxd
+        # Provides libasan/libubsan
+        gcc
         # Required to run systemd-networkd-tests.py
         python3
         iproute2
diff --git a/mkosi.postinst b/mkosi.postinst
index 6eddadfea8..8817818a94 100755
--- a/mkosi.postinst
+++ b/mkosi.postinst
@@ -1,8 +1,18 @@
 #!/bin/sh
 # SPDX-License-Identifier: LGPL-2.1-or-later
 
-if [ "$1" = "final" ] && command -v bootctl > /dev/null && [ -d "/efi" ]; then
-    bootctl install
+if [ "$1" = "final" ]; then
+    if command -v bootctl > /dev/null && [ -d "/efi" ]; then
+        bootctl install
+    fi
+
+    if [ -n "$SANITIZERS" ]; then
+        # ASAN and syscall filters aren't compatible with each other.
+        find / -name '*.service' -type f -exec sed -i 's/^\(MemoryDeny\|SystemCall\)/# \1/' {} +
+
+        # `systemd-hwdb update` takes > 50s when built with sanitizers so let's not run it by default.
+        systemctl mask systemd-hwdb-update.service
+    fi
 fi
 
 # Temporary workaround until https://github.com/openSUSE/suse-module-tools/commit/158643414ddb8d8208016a5f03a4484d58944d7a