diff --git a/Ports/ncurses/patches/0002-Disable-mixed-case-directory-names-when-building-on-.patch b/Ports/ncurses/patches/0002-Disable-mixed-case-directory-names-when-building-on-.patch
new file mode 100644
index 0000000000..67630eb3eb
--- /dev/null
+++ b/Ports/ncurses/patches/0002-Disable-mixed-case-directory-names-when-building-on-.patch
@@ -0,0 +1,32 @@
+From 0000000000000000000000000000000000000000 Mon Sep 17 00:00:00 2001
+From: SeekingBlues <seekingblues@gmail.com>
+Date: Sun, 19 Jun 2022 18:36:27 +0800
+Subject: [PATCH] Disable mixed-case directory names when building on macOS
+
+Since macOS's filesystem is case-insensitive, its `tic` only generates
+terminfo directory names that are hex numbers instead of letters, such
+as 78/xterm instead of x/xterm. However, the configure script still
+enables the mixed-case directory name feature by default. As a result,
+ncurses will fail when trying to find terminfo entries like x/xterm if
+they are generated on macOS.
+
+It seems like there is no way to change the behavior of `tic` to create
+alphabetical directories, so we can only disable this option explicitly.
+---
+ configure | 3 +++
+ 1 file changed, 3 insertions(+)
+
+diff --git a/configure b/configure
+index 31bbb85..478eabd 100755
+--- a/configure
++++ b/configure
+@@ -4361,6 +4361,9 @@ if test "$cross_compiling" = yes ; then
+ 		cf_cv_mixedcase=yes
+ 		;;
+ 	esac
++	if test "$(uname)" = Darwin; then
++		cf_cv_mixedcase=no
++	fi
+ else
+ 	rm -f conftest CONFTEST
+ 	echo test >conftest
diff --git a/Ports/ncurses/patches/ReadMe.md b/Ports/ncurses/patches/ReadMe.md
index 295686d84a..1cd0b2b83a 100644
--- a/Ports/ncurses/patches/ReadMe.md
+++ b/Ports/ncurses/patches/ReadMe.md
@@ -5,3 +5,17 @@
 Teach configure about serenity
 
 
+## `0002-Disable-mixed-case-directory-names-when-building-on-.patch`
+
+Disable mixed-case directory names when building on macOS
+
+Since macOS's filesystem is case-insensitive, its `tic` only generates
+terminfo directory names that are hex numbers instead of letters, such
+as 78/xterm instead of x/xterm. However, the configure script still
+enables the mixed-case directory name feature by default. As a result,
+ncurses will fail when trying to find terminfo entries like x/xterm if
+they are generated on macOS.
+
+It seems like there is no way to change the behavior of `tic` to create
+alphabetical directories, so we can only disable this option explicitly.
+