diff --git a/requirements_test.txt b/requirements_test.txt
index 8ec5a611f1d8..e4553a2498b9 100644
--- a/requirements_test.txt
+++ b/requirements_test.txt
@@ -24,6 +24,6 @@ pytest-xdist==2.1.0
 pytest==6.1.2
 requests_mock==1.8.0
 responses==0.12.0
-respx==0.14.0
+respx==0.16.2
 stdlib-list==0.7.0
 tqdm==4.49.0
diff --git a/tests/components/rest/test_binary_sensor.py b/tests/components/rest/test_binary_sensor.py
index 48d13a716abc..2638477ef794 100644
--- a/tests/components/rest/test_binary_sensor.py
+++ b/tests/components/rest/test_binary_sensor.py
@@ -18,7 +18,7 @@ from homeassistant.const import (
 )
 from homeassistant.setup import async_setup_component
 
-from tests.async_mock import Mock, patch
+from tests.async_mock import patch
 
 
 async def test_setup_missing_basic_config(hass):
@@ -50,9 +50,7 @@ async def test_setup_missing_config(hass):
 @respx.mock
 async def test_setup_failed_connect(hass):
     """Test setup when connection error occurs."""
-    respx.get(
-        "http://localhost", content=httpx.RequestError(message="any", request=Mock())
-    )
+    respx.get("http://localhost").mock(side_effect=httpx.RequestError)
     assert await async_setup_component(
         hass,
         binary_sensor.DOMAIN,
@@ -71,7 +69,7 @@ async def test_setup_failed_connect(hass):
 @respx.mock
 async def test_setup_timeout(hass):
     """Test setup when connection timeout occurs."""
-    respx.get("http://localhost", content=asyncio.TimeoutError())
+    respx.get("http://localhost").mock(side_effect=asyncio.TimeoutError())
     assert await async_setup_component(
         hass,
         binary_sensor.DOMAIN,
@@ -90,7 +88,7 @@ async def test_setup_timeout(hass):
 @respx.mock
 async def test_setup_minimum(hass):
     """Test setup with minimum configuration."""
-    respx.get("http://localhost", status_code=200)
+    respx.get("http://localhost") % 200
     assert await async_setup_component(
         hass,
         binary_sensor.DOMAIN,
@@ -109,7 +107,7 @@ async def test_setup_minimum(hass):
 @respx.mock
 async def test_setup_minimum_resource_template(hass):
     """Test setup with minimum configuration (resource_template)."""
-    respx.get("http://localhost", status_code=200)
+    respx.get("http://localhost") % 200
     assert await async_setup_component(
         hass,
         binary_sensor.DOMAIN,
@@ -127,7 +125,7 @@ async def test_setup_minimum_resource_template(hass):
 @respx.mock
 async def test_setup_duplicate_resource_template(hass):
     """Test setup with duplicate resources."""
-    respx.get("http://localhost", status_code=200)
+    respx.get("http://localhost") % 200
     assert await async_setup_component(
         hass,
         binary_sensor.DOMAIN,
@@ -146,7 +144,7 @@ async def test_setup_duplicate_resource_template(hass):
 @respx.mock
 async def test_setup_get(hass):
     """Test setup with valid configuration."""
-    respx.get("http://localhost", status_code=200, content="{}")
+    respx.get("http://localhost").respond(status_code=200, json={})
     assert await async_setup_component(
         hass,
         "binary_sensor",
@@ -174,7 +172,7 @@ async def test_setup_get(hass):
 @respx.mock
 async def test_setup_get_digest_auth(hass):
     """Test setup with valid configuration."""
-    respx.get("http://localhost", status_code=200, content="{}")
+    respx.get("http://localhost").respond(status_code=200, json={})
     assert await async_setup_component(
         hass,
         "binary_sensor",
@@ -202,7 +200,7 @@ async def test_setup_get_digest_auth(hass):
 @respx.mock
 async def test_setup_post(hass):
     """Test setup with valid configuration."""
-    respx.post("http://localhost", status_code=200, content="{}")
+    respx.post("http://localhost").respond(status_code=200, json={})
     assert await async_setup_component(
         hass,
         "binary_sensor",
@@ -230,11 +228,10 @@ async def test_setup_post(hass):
 @respx.mock
 async def test_setup_get_off(hass):
     """Test setup with valid off configuration."""
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": "text/json"},
-        content='{"dog": false}',
+        json={"dog": False},
     )
     assert await async_setup_component(
         hass,
@@ -261,11 +258,10 @@ async def test_setup_get_off(hass):
 @respx.mock
 async def test_setup_get_on(hass):
     """Test setup with valid on configuration."""
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": "text/json"},
-        content='{"dog": true}',
+        json={"dog": True},
     )
     assert await async_setup_component(
         hass,
@@ -292,7 +288,7 @@ async def test_setup_get_on(hass):
 @respx.mock
 async def test_setup_with_exception(hass):
     """Test setup with exception."""
-    respx.get("http://localhost", status_code=200, content="{}")
+    respx.get("http://localhost").respond(status_code=200, json={})
     assert await async_setup_component(
         hass,
         "binary_sensor",
@@ -318,9 +314,7 @@ async def test_setup_with_exception(hass):
     await hass.async_block_till_done()
 
     respx.clear()
-    respx.get(
-        "http://localhost", content=httpx.RequestError(message="any", request=Mock())
-    )
+    respx.get("http://localhost").mock(side_effect=httpx.RequestError)
     await hass.services.async_call(
         "homeassistant",
         "update_entity",
@@ -337,7 +331,7 @@ async def test_setup_with_exception(hass):
 async def test_reload(hass):
     """Verify we can reload reset sensors."""
 
-    respx.get("http://localhost", status_code=200)
+    respx.get("http://localhost") % 200
 
     await async_setup_component(
         hass,
@@ -380,10 +374,7 @@ async def test_reload(hass):
 @respx.mock
 async def test_setup_query_params(hass):
     """Test setup with query params."""
-    respx.get(
-        "http://localhost?search=something",
-        status_code=200,
-    )
+    respx.get("http://localhost", params={"search": "something"}) % 200
     assert await async_setup_component(
         hass,
         binary_sensor.DOMAIN,
diff --git a/tests/components/rest/test_sensor.py b/tests/components/rest/test_sensor.py
index 71bcbedda88b..f378a1fc2a11 100644
--- a/tests/components/rest/test_sensor.py
+++ b/tests/components/rest/test_sensor.py
@@ -16,7 +16,7 @@ from homeassistant.const import (
 )
 from homeassistant.setup import async_setup_component
 
-from tests.async_mock import Mock, patch
+from tests.async_mock import patch
 
 
 async def test_setup_missing_config(hass):
@@ -42,9 +42,7 @@ async def test_setup_missing_schema(hass):
 @respx.mock
 async def test_setup_failed_connect(hass):
     """Test setup when connection error occurs."""
-    respx.get(
-        "http://localhost", content=httpx.RequestError(message="any", request=Mock())
-    )
+    respx.get("http://localhost").mock(side_effect=httpx.RequestError)
     assert await async_setup_component(
         hass,
         sensor.DOMAIN,
@@ -63,7 +61,7 @@ async def test_setup_failed_connect(hass):
 @respx.mock
 async def test_setup_timeout(hass):
     """Test setup when connection timeout occurs."""
-    respx.get("http://localhost", content=asyncio.TimeoutError())
+    respx.get("http://localhost").mock(side_effect=asyncio.TimeoutError())
     assert await async_setup_component(
         hass,
         sensor.DOMAIN,
@@ -76,7 +74,7 @@ async def test_setup_timeout(hass):
 @respx.mock
 async def test_setup_minimum(hass):
     """Test setup with minimum configuration."""
-    respx.get("http://localhost", status_code=200)
+    respx.get("http://localhost") % 200
     assert await async_setup_component(
         hass,
         sensor.DOMAIN,
@@ -95,7 +93,7 @@ async def test_setup_minimum(hass):
 @respx.mock
 async def test_setup_minimum_resource_template(hass):
     """Test setup with minimum configuration (resource_template)."""
-    respx.get("http://localhost", status_code=200)
+    respx.get("http://localhost") % 200
     assert await async_setup_component(
         hass,
         sensor.DOMAIN,
@@ -113,7 +111,7 @@ async def test_setup_minimum_resource_template(hass):
 @respx.mock
 async def test_setup_duplicate_resource_template(hass):
     """Test setup with duplicate resources."""
-    respx.get("http://localhost", status_code=200)
+    respx.get("http://localhost") % 200
     assert await async_setup_component(
         hass,
         sensor.DOMAIN,
@@ -132,7 +130,7 @@ async def test_setup_duplicate_resource_template(hass):
 @respx.mock
 async def test_setup_get(hass):
     """Test setup with valid configuration."""
-    respx.get("http://localhost", status_code=200, content="{}")
+    respx.get("http://localhost").respond(status_code=200, json={})
     assert await async_setup_component(
         hass,
         "sensor",
@@ -161,7 +159,7 @@ async def test_setup_get(hass):
 @respx.mock
 async def test_setup_get_digest_auth(hass):
     """Test setup with valid configuration."""
-    respx.get("http://localhost", status_code=200, content="{}")
+    respx.get("http://localhost").respond(status_code=200, json={})
     assert await async_setup_component(
         hass,
         "sensor",
@@ -190,7 +188,7 @@ async def test_setup_get_digest_auth(hass):
 @respx.mock
 async def test_setup_post(hass):
     """Test setup with valid configuration."""
-    respx.post("http://localhost", status_code=200, content="{}")
+    respx.post("http://localhost").respond(status_code=200, json={})
     assert await async_setup_component(
         hass,
         "sensor",
@@ -219,8 +217,7 @@ async def test_setup_post(hass):
 @respx.mock
 async def test_setup_get_xml(hass):
     """Test setup with valid xml configuration."""
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": "text/xml"},
         content="<dog>abc</dog>",
@@ -252,10 +249,7 @@ async def test_setup_get_xml(hass):
 @respx.mock
 async def test_setup_query_params(hass):
     """Test setup with query params."""
-    respx.get(
-        "http://localhost?search=something",
-        status_code=200,
-    )
+    respx.get("http://localhost", params={"search": "something"}) % 200
     assert await async_setup_component(
         hass,
         sensor.DOMAIN,
@@ -276,11 +270,9 @@ async def test_setup_query_params(hass):
 async def test_update_with_json_attrs(hass):
     """Test attributes get extracted from a JSON result."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
-        headers={"content-type": CONTENT_TYPE_JSON},
-        content='{ "key": "some_json_value" }',
+        json={"key": "some_json_value"},
     )
     assert await async_setup_component(
         hass,
@@ -311,11 +303,9 @@ async def test_update_with_json_attrs(hass):
 async def test_update_with_no_template(hass):
     """Test update when there is no value template."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
-        headers={"content-type": CONTENT_TYPE_JSON},
-        content='{ "key": "some_json_value" }',
+        json={"key": "some_json_value"},
     )
     assert await async_setup_component(
         hass,
@@ -338,15 +328,14 @@ async def test_update_with_no_template(hass):
     assert len(hass.states.async_all()) == 1
 
     state = hass.states.get("sensor.foo")
-    assert state.state == '{ "key": "some_json_value" }'
+    assert state.state == '{"key": "some_json_value"}'
 
 
 @respx.mock
 async def test_update_with_json_attrs_no_data(hass, caplog):
     """Test attributes when no JSON result fetched."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": CONTENT_TYPE_JSON},
         content="",
@@ -382,11 +371,9 @@ async def test_update_with_json_attrs_no_data(hass, caplog):
 async def test_update_with_json_attrs_not_dict(hass, caplog):
     """Test attributes get extracted from a JSON result."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
-        headers={"content-type": CONTENT_TYPE_JSON},
-        content='["list", "of", "things"]',
+        json=["list", "of", "things"],
     )
     assert await async_setup_component(
         hass,
@@ -419,8 +406,7 @@ async def test_update_with_json_attrs_not_dict(hass, caplog):
 async def test_update_with_json_attrs_bad_JSON(hass, caplog):
     """Test attributes get extracted from a JSON result."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": CONTENT_TYPE_JSON},
         content="This is text rather than JSON data.",
@@ -456,11 +442,17 @@ async def test_update_with_json_attrs_bad_JSON(hass, caplog):
 async def test_update_with_json_attrs_with_json_attrs_path(hass):
     """Test attributes get extracted from a JSON result with a template for the attributes."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
-        headers={"content-type": CONTENT_TYPE_JSON},
-        content='{ "toplevel": {"master_value": "master", "second_level": {"some_json_key": "some_json_value", "some_json_key2": "some_json_value2" } } }',
+        json={
+            "toplevel": {
+                "master_value": "master",
+                "second_level": {
+                    "some_json_key": "some_json_value",
+                    "some_json_key2": "some_json_value2",
+                },
+            },
+        },
     )
     assert await async_setup_component(
         hass,
@@ -494,8 +486,7 @@ async def test_update_with_json_attrs_with_json_attrs_path(hass):
 async def test_update_with_xml_convert_json_attrs_with_json_attrs_path(hass):
     """Test attributes get extracted from a JSON result that was converted from XML with a template for the attributes."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": "text/xml"},
         content="<toplevel><master_value>master</master_value><second_level><some_json_key>some_json_value</some_json_key><some_json_key2>some_json_value2</some_json_key2></second_level></toplevel>",
@@ -531,8 +522,7 @@ async def test_update_with_xml_convert_json_attrs_with_json_attrs_path(hass):
 async def test_update_with_xml_convert_json_attrs_with_jsonattr_template(hass):
     """Test attributes get extracted from a JSON result that was converted from XML."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": "text/xml"},
         content='<?xml version="1.0" encoding="utf-8"?><response><scan>0</scan><ver>12556</ver><count>48</count><ssid>alexander</ssid><bss><valid>0</valid><name>0</name><privacy>0</privacy><wlan>bogus</wlan><strength>0</strength></bss><led0>0</led0><led1>0</led1><led2>0</led2><led3>0</led3><led4>0</led4><led5>0</led5><led6>0</led6><led7>0</led7><btn0>up</btn0><btn1>up</btn1><btn2>up</btn2><btn3>up</btn3><pot0>0</pot0><usr0>0</usr0><temp0>0x0XF0x0XF</temp0><time0> 0</time0></response>',
@@ -573,8 +563,7 @@ async def test_update_with_application_xml_convert_json_attrs_with_jsonattr_temp
 ):
     """Test attributes get extracted from a JSON result that was converted from XML with application/xml mime type."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": "application/xml"},
         content="<main><dog>1</dog><cat>3</cat></main>",
@@ -610,8 +599,7 @@ async def test_update_with_application_xml_convert_json_attrs_with_jsonattr_temp
 async def test_update_with_xml_convert_bad_xml(hass, caplog):
     """Test attributes get extracted from a XML result with bad xml."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": "text/xml"},
         content="",
@@ -646,8 +634,7 @@ async def test_update_with_xml_convert_bad_xml(hass, caplog):
 async def test_update_with_failed_get(hass, caplog):
     """Test attributes get extracted from a XML result with bad xml."""
 
-    respx.get(
-        "http://localhost",
+    respx.get("http://localhost").respond(
         status_code=200,
         headers={"content-type": "text/xml"},
         content="",
@@ -682,7 +669,7 @@ async def test_update_with_failed_get(hass, caplog):
 async def test_reload(hass):
     """Verify we can reload reset sensors."""
 
-    respx.get("http://localhost", status_code=200)
+    respx.get("http://localhost") % 200
 
     await async_setup_component(
         hass,