diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index d921286ba34..79aba249111 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -293,6 +293,7 @@ jobs:
               MACOSX_DEPLOYMENT_TARGET: 10.7
               NO_LLVM_ASSERTIONS: 1
               NO_DEBUG_ASSERTIONS: 1
+              NO_OVERFLOW_CHECKS: 1
               DIST_REQUIRE_ALL_TOOLS: 1
             os: macos-latest
           - name: dist-x86_64-apple-alt
@@ -303,6 +304,7 @@ jobs:
               MACOSX_DEPLOYMENT_TARGET: 10.7
               NO_LLVM_ASSERTIONS: 1
               NO_DEBUG_ASSERTIONS: 1
+              NO_OVERFLOW_CHECKS: 1
             os: macos-latest
           - name: x86_64-apple
             env:
@@ -313,6 +315,7 @@ jobs:
               MACOSX_STD_DEPLOYMENT_TARGET: 10.7
               NO_LLVM_ASSERTIONS: 1
               NO_DEBUG_ASSERTIONS: 1
+              NO_OVERFLOW_CHECKS: 1
             os: macos-latest
           - name: dist-aarch64-apple
             env:
@@ -324,6 +327,7 @@ jobs:
               MACOSX_STD_DEPLOYMENT_TARGET: 11.0
               NO_LLVM_ASSERTIONS: 1
               NO_DEBUG_ASSERTIONS: 1
+              NO_OVERFLOW_CHECKS: 1
               DIST_REQUIRE_ALL_TOOLS: 1
               JEMALLOC_SYS_WITH_LG_PAGE: 14
             os: macos-latest
diff --git a/src/ci/docker/host-x86_64/disabled/asmjs/Dockerfile b/src/ci/docker/host-x86_64/disabled/asmjs/Dockerfile
index e04f6409f54..07dcb9ea928 100644
--- a/src/ci/docker/host-x86_64/disabled/asmjs/Dockerfile
+++ b/src/ci/docker/host-x86_64/disabled/asmjs/Dockerfile
@@ -40,3 +40,4 @@ ENV SCRIPT python3 ../x.py --stage 2 test --host='' --target $TARGETS
 # running with assertions again is not useful
 ENV NO_DEBUG_ASSERTIONS=1
 ENV NO_LLVM_ASSERTIONS=1
+ENV NO_OVERFLOW_CHECKS=1
diff --git a/src/ci/docker/host-x86_64/test-various/Dockerfile b/src/ci/docker/host-x86_64/test-various/Dockerfile
index ad0e8e9f928..4d4953fa0e2 100644
--- a/src/ci/docker/host-x86_64/test-various/Dockerfile
+++ b/src/ci/docker/host-x86_64/test-various/Dockerfile
@@ -39,6 +39,7 @@ ENV RUST_CONFIGURE_ARGS \
 # otherwise normally be. We already test libstd with debug assertions in lots of
 # other contexts as well
 ENV NO_DEBUG_ASSERTIONS=1
+ENV NO_OVERFLOW_CHECKS=1
 
 ENV WASM_TARGETS=wasm32-unknown-unknown
 ENV WASM_SCRIPT python3 /checkout/x.py --stage 2 test --host='' --target $WASM_TARGETS \
diff --git a/src/ci/github-actions/ci.yml b/src/ci/github-actions/ci.yml
index eb16cf3c762..82f184669ee 100644
--- a/src/ci/github-actions/ci.yml
+++ b/src/ci/github-actions/ci.yml
@@ -456,6 +456,7 @@ jobs:
               MACOSX_DEPLOYMENT_TARGET: 10.7
               NO_LLVM_ASSERTIONS: 1
               NO_DEBUG_ASSERTIONS: 1
+              NO_OVERFLOW_CHECKS: 1
               DIST_REQUIRE_ALL_TOOLS: 1
             <<: *job-macos-xl
 
@@ -467,6 +468,7 @@ jobs:
               MACOSX_DEPLOYMENT_TARGET: 10.7
               NO_LLVM_ASSERTIONS: 1
               NO_DEBUG_ASSERTIONS: 1
+              NO_OVERFLOW_CHECKS: 1
             <<: *job-macos-xl
 
           - name: x86_64-apple
@@ -478,6 +480,7 @@ jobs:
               MACOSX_STD_DEPLOYMENT_TARGET: 10.7
               NO_LLVM_ASSERTIONS: 1
               NO_DEBUG_ASSERTIONS: 1
+              NO_OVERFLOW_CHECKS: 1
             <<: *job-macos-xl
 
           # This target only needs to support 11.0 and up as nothing else supports the hardware
@@ -499,6 +502,7 @@ jobs:
               MACOSX_STD_DEPLOYMENT_TARGET: 11.0
               NO_LLVM_ASSERTIONS: 1
               NO_DEBUG_ASSERTIONS: 1
+              NO_OVERFLOW_CHECKS: 1
               DIST_REQUIRE_ALL_TOOLS: 1
               # Corresponds to 16K page size
               #
diff --git a/src/ci/run.sh b/src/ci/run.sh
index b5019d83af4..3644269a0f6 100755
--- a/src/ci/run.sh
+++ b/src/ci/run.sh
@@ -89,6 +89,11 @@ else
     RUST_CONFIGURE_ARGS="$RUST_CONFIGURE_ARGS --enable-debug-assertions"
   fi
 
+  # Same for overflow checks
+  if [ "$NO_OVERFLOW_CHECKS" = "" ]; then
+    RUST_CONFIGURE_ARGS="$RUST_CONFIGURE_ARGS --enable-overflow-checks"
+  fi
+
   # In general we always want to run tests with LLVM assertions enabled, but not
   # all platforms currently support that, so we have an option to disable.
   if [ "$NO_LLVM_ASSERTIONS" = "" ]; then