diff --git a/compiler/rustc_codegen_ssa/src/codegen_attrs.rs b/compiler/rustc_codegen_ssa/src/codegen_attrs.rs
index dac7d2e89b1..8542bab689d 100644
--- a/compiler/rustc_codegen_ssa/src/codegen_attrs.rs
+++ b/compiler/rustc_codegen_ssa/src/codegen_attrs.rs
@@ -103,7 +103,22 @@ fn codegen_fn_attrs(tcx: TyCtxt<'_>, did: LocalDefId) -> CodegenFnAttrs {
                 codegen_fn_attrs.flags |= CodegenFnAttrFlags::ALLOCATOR_ZEROED
             }
             sym::naked => codegen_fn_attrs.flags |= CodegenFnAttrFlags::NAKED,
-            sym::no_mangle => codegen_fn_attrs.flags |= CodegenFnAttrFlags::NO_MANGLE,
+            sym::no_mangle => {
+                if tcx.opt_item_name(did.to_def_id()).is_some() {
+                    codegen_fn_attrs.flags |= CodegenFnAttrFlags::NO_MANGLE
+                } else {
+                    tcx.sess
+                        .struct_span_err(
+                            attr.span,
+                            format!(
+                                "`#[no_mangle]` cannot be used on {} {} as it has no name",
+                                tcx.def_descr_article(did.to_def_id()),
+                                tcx.def_descr(did.to_def_id()),
+                            ),
+                        )
+                        .emit();
+                }
+            }
             sym::no_coverage => codegen_fn_attrs.flags |= CodegenFnAttrFlags::NO_COVERAGE,
             sym::rustc_std_internal_symbol => {
                 codegen_fn_attrs.flags |= CodegenFnAttrFlags::RUSTC_STD_INTERNAL_SYMBOL
diff --git a/tests/ui/attributes/no-mangle-closure.rs b/tests/ui/attributes/no-mangle-closure.rs
new file mode 100644
index 00000000000..c76baa27f38
--- /dev/null
+++ b/tests/ui/attributes/no-mangle-closure.rs
@@ -0,0 +1,11 @@
+// Check that we do not ICE when `no_mangle` is applied to something that has no name.
+
+#![crate_type = "lib"]
+#![feature(stmt_expr_attributes)]
+
+pub struct S([usize; 8]);
+
+pub fn outer_function(x: S, y: S) -> usize {
+    (#[no_mangle] || y.0[0])()
+    //~^ ERROR `#[no_mangle]` cannot be used on a closure as it has no name
+}
diff --git a/tests/ui/attributes/no-mangle-closure.stderr b/tests/ui/attributes/no-mangle-closure.stderr
new file mode 100644
index 00000000000..949eb70510e
--- /dev/null
+++ b/tests/ui/attributes/no-mangle-closure.stderr
@@ -0,0 +1,8 @@
+error: `#[no_mangle]` cannot be used on a closure as it has no name
+  --> $DIR/no-mangle-closure.rs:9:6
+   |
+LL |     (#[no_mangle] || y.0[0])()
+   |      ^^^^^^^^^^^^
+
+error: aborting due to previous error
+