diff --git a/src/cmd/compile/internal/gc/walk.go b/src/cmd/compile/internal/gc/walk.go
index 2133a160b2..98ebb23991 100644
--- a/src/cmd/compile/internal/gc/walk.go
+++ b/src/cmd/compile/internal/gc/walk.go
@@ -550,8 +550,12 @@ opswitch:
 	case OCLOSUREVAR, OCFUNC:
 
 	case OCALLINTER, OCALLFUNC, OCALLMETH:
-		if n.Op == OCALLINTER {
+		if n.Op == OCALLINTER || n.Op == OCALLMETH {
+			// We expect both interface call reflect.Type.Method and concrete
+			// call reflect.(*rtype).Method.
 			usemethod(n)
+		}
+		if n.Op == OCALLINTER {
 			markUsedIfaceMethod(n)
 		}
 
@@ -3710,6 +3714,16 @@ func usemethod(n *Node) {
 		}
 	}
 
+	// Don't mark reflect.(*rtype).Method, etc. themselves in the reflect package.
+	// Those functions may be alive via the itab, which should not cause all methods
+	// alive. We only want to mark their callers.
+	if myimportpath == "reflect" {
+		switch Curfn.Func.Nname.Sym.Name { // TODO: is there a better way than hardcoding the names?
+		case "(*rtype).Method", "(*rtype).MethodByName", "(*interfaceType).Method", "(*interfaceType).MethodByName":
+			return
+		}
+	}
+
 	// Note: Don't rely on res0.Type.String() since its formatting depends on multiple factors
 	//       (including global variables such as numImports - was issue #19028).
 	// Also need to check for reflect package itself (see Issue #38515).
diff --git a/test/reflectmethod7.go b/test/reflectmethod7.go
new file mode 100644
index 0000000000..42429978b4
--- /dev/null
+++ b/test/reflectmethod7.go
@@ -0,0 +1,24 @@
+// run
+
+// Copyright 2021 The Go Authors. All rights reserved.
+// Use of this source code is governed by a BSD-style
+// license that can be found in the LICENSE file.
+
+// See issue 44207.
+
+package main
+
+import "reflect"
+
+type S int
+
+func (s S) M() {}
+
+func main() {
+	t := reflect.TypeOf(S(0))
+	fn, ok := reflect.PtrTo(t).MethodByName("M")
+	if !ok {
+		panic("FAIL")
+	}
+	fn.Func.Call([]reflect.Value{reflect.New(t)})
+}