diff --git a/src/cmd/go/internal/test/test.go b/src/cmd/go/internal/test/test.go
index cfb0a1465f..7dca6b531c 100644
--- a/src/cmd/go/internal/test/test.go
+++ b/src/cmd/go/internal/test/test.go
@@ -666,6 +666,12 @@ func runTest(ctx context.Context, cmd *base.Command, args []string) {
 		if len(pkgs) != 1 {
 			base.Fatalf("cannot use -fuzz flag with multiple packages")
 		}
+		if testCoverProfile != "" {
+			base.Fatalf("cannot use -coverprofile flag with -fuzz flag")
+		}
+		if profileFlag := testProfile(); profileFlag != "" {
+			base.Fatalf("cannot use %s flag with -fuzz flag", profileFlag)
+		}
 
 		// Reject the '-fuzz' flag if the package is outside the main module.
 		// Otherwise, if fuzzing identifies a failure it could corrupt checksums in
diff --git a/src/cmd/go/testdata/script/test_fuzz_profile_flags.txt b/src/cmd/go/testdata/script/test_fuzz_profile_flags.txt
new file mode 100644
index 0000000000..5434c723ad
--- /dev/null
+++ b/src/cmd/go/testdata/script/test_fuzz_profile_flags.txt
@@ -0,0 +1,38 @@
+[!fuzz] skip
+
+! go test -fuzz=FuzzTrivial -coverprofile=prof
+! stdout .
+stderr '^cannot use -coverprofile flag with -fuzz flag$'
+
+! go test -fuzz=FuzzTrivial -blockprofile=prof
+! stdout .
+stderr '^cannot use -blockprofile flag with -fuzz flag$'
+
+! go test -fuzz=FuzzTrivial -cpuprofile=prof
+! stdout .
+stderr '^cannot use -cpuprofile flag with -fuzz flag$'
+
+! go test -fuzz=FuzzTrivial -memprofile=prof
+! stdout .
+stderr '^cannot use -memprofile flag with -fuzz flag$'
+
+! go test -fuzz=FuzzTrivial -mutexprofile=prof
+! stdout .
+stderr '^cannot use -mutexprofile flag with -fuzz flag$'
+
+! go test -fuzz=FuzzTrivial -trace=prof
+! stdout .
+stderr '^cannot use -trace flag with -fuzz flag$'
+
+-- go.mod --
+module example
+
+go 1.18
+-- fuzz_test.go --
+package example
+
+import "testing"
+
+func FuzzTrivial(f *testing.F) {
+	f.Fuzz(func(t *testing.T, _ []byte) {})
+}