diff --git a/pkg/status_file/test/data/standalone_2_vm.status b/pkg/status_file/test/data/standalone_2_vm.status
index d58085f65bc..2ce625eb30f 100644
--- a/pkg/status_file/test/data/standalone_2_vm.status
+++ b/pkg/status_file/test/data/standalone_2_vm.status
@@ -17,7 +17,7 @@ io/regress_7191_test: Pass, Timeout # Issue 28374: timeout.
 [ $runtime == vm && $system == macos && $mode == release ]
 io/named_pipe_script_test: Pass, RuntimeError # Issue 28737
 
-[ $runtime == vm && $system == linux && $mode == release && $arch == ia32 && $builder_tag == asan ]
+[ $runtime == vm && $system == linux && $mode == release && $arch == ia32 && $sanitizer == asan ]
 io/socket_close_test: Pass, Timeout # Issue 28502: timeout.
 
 [ $arch == ia32 ]
diff --git a/pkg/status_file/test/data/vm.status b/pkg/status_file/test/data/vm.status
index d5e0d99afa0..3b59b0fe2d1 100644
--- a/pkg/status_file/test/data/vm.status
+++ b/pkg/status_file/test/data/vm.status
@@ -131,7 +131,7 @@ dart/spawn_infinite_loop_test: Skip  # VM shutdown test
 dart/spawn_shutdown_test: Skip  # VM Shutdown test
 dart/hello_fuchsia_test: SkipByDesign # This is a test for fuchsia OS
 
-[ $builder_tag == asan ]
+[ $sanitizer == asan ]
 cc/CodeImmutability: Fail,OK # Address Sanitizer turns a crash into a failure.
 cc/IsolateReload_DanglingGetter_Class: Fail # Issue 28349
 cc/IsolateReload_DanglingGetter_Instance: Fail # Issue 28349
diff --git a/pkg/test_runner/lib/src/environment.dart b/pkg/test_runner/lib/src/environment.dart
index fe005b573ad..dc170fbe729 100644
--- a/pkg/test_runner/lib/src/environment.dart
+++ b/pkg/test_runner/lib/src/environment.dart
@@ -33,6 +33,7 @@ final _variables = {
   "nnbd": _Variable((TestConfiguration c) => c.nnbdMode.name, NnbdMode.names),
   "qemu": _Variable.bool((c) => c.useQemu),
   "runtime": _Variable(_runtimeName, _runtimeNames),
+  "sanitizer": _Variable((c) => c.sanitizer.name, Sanitizer.names),
   "simulator": _Variable.bool((c) => c.isSimulator),
   "spec_parser": _Variable.bool((c) => c.compiler == Compiler.specParser),
   "system": _Variable(_systemName, _systemNames),
diff --git a/pkg/test_runner/lib/src/runtime_configuration.dart b/pkg/test_runner/lib/src/runtime_configuration.dart
index f3e5973191f..3764f6fcb5b 100644
--- a/pkg/test_runner/lib/src/runtime_configuration.dart
+++ b/pkg/test_runner/lib/src/runtime_configuration.dart
@@ -320,7 +320,7 @@ class DartVmRuntimeConfiguration extends RuntimeConfiguration {
       multiplier *= 2;
     }
     if (_configuration.sanitizer != Sanitizer.none) {
-      multiplier *= 2;
+      multiplier *= 4;
     }
     if (_configuration.rr) {
       multiplier *= 2;
diff --git a/runtime/tests/vm/vm.status b/runtime/tests/vm/vm.status
index 8c252b3bd30..c7d1ac7c401 100644
--- a/runtime/tests/vm/vm.status
+++ b/runtime/tests/vm/vm.status
@@ -59,10 +59,6 @@ dart_2/disassemble_aot_test: SkipByDesign # IA32 does not support AOT.
 dart_2/regress32597_2_test: Pass, Slow # Uses --optimization-counter-threshold=10 without a kernel service snapshot.
 dart_2/regress38467_test: Pass, Slow # Uses --optimization-counter-threshold=10 without a kernel service snapshot.
 
-[ $builder_tag == asan ]
-dart/transferable_throws_oom_test: SkipByDesign # This test tries to allocate too much memory on purpose. Still dartbug.com/37188
-dart_2/transferable_throws_oom_test: SkipByDesign # This test tries to allocate too much memory on purpose. Still dartbug.com/37188
-
 [ $builder_tag == obfuscated ]
 dart/heapsnapshot_cli_test: SkipByDesign # Relies on symbol names
 dart/isolate_exit_unsendable_test: SkipByDesign # Relies on symbol names
@@ -84,34 +80,6 @@ dart_2/kernel_determinism_test: SkipSlow
 dart_2/minimal_kernel_test: SkipSlow # gen_kernel is too slow with optimization_counter_threshold
 dart_2/null_safety_autodetection_in_kernel_compiler_test: SkipSlow # gen_kernel is too slow with optimization_counter_threshold
 
-[ $builder_tag == tsan ]
-dart/analyze_snapshot_binary_test: SkipSlow
-dart/appjit_cha_deopt_test: SkipSlow
-dart/gc/fragmentation*: Skip # Uses too much memory with TSAN overhead and kills bot
-dart/gc/out_of_memory*: Skip # Uses too much memory with TSAN overhead and kills bot
-dart/gc/scavenger_abort_test: SkipSlow
-dart/hash_map_probes_limit_test: SkipSlow # Test includes large program compilation.
-dart/regress_40462_test: SkipSlow
-dart/regress_40753_test: Skip # This test crashes on the bot, but not locally, and infrastructure repeatedly fails to locate its coredump.
-dart/regress_48523_test: Pass, Slow
-dart/trigger_gc_in_native_test: Skip # This test crashes on the bot, but not locally, and infrastructure repeatedly fails to locate its coredump.
-dart/unobfuscated_static_symbols_test: Pass, Slow # Test includes creating several snapshots in both ELF and assembly modes.
-dart/use_strip_flag_test: Pass, Slow # This test can take a longer time to complete.
-dart/v8_snapshot_profile_writer_test: SkipSlow
-dart/weak_canonical_string_table_test: Pass, Slow # This test can take a longer time to complete.
-dart_2/analyze_snapshot_binary_test: SkipSlow
-dart_2/appjit_cha_deopt_test: SkipSlow
-dart_2/gc/fragmentation*: Skip # Uses too much memory with TSAN overhead and kills bot
-dart_2/gc/out_of_memory*: Skip # Uses too much memory with TSAN overhead and kills bot
-dart_2/gc/scavenger_abort_test: SkipSlow
-dart_2/hash_map_probes_limit_test: SkipSlow # Test includes large program compilation.
-dart_2/regress_40462_test: SkipSlow
-dart_2/regress_40753_test: Skip # This test crashes on the bot, but not locally, and infrastructure repeatedly fails to locate its coredump.
-dart_2/trigger_gc_in_native_test: Skip # This test crashes on the bot, but not locally, and infrastructure repeatedly fails to locate its coredump.
-dart_2/use_strip_flag_test: Pass, Slow # This test can take a longer time to complete.
-dart_2/v8_snapshot_profile_writer_test: SkipSlow
-dart_2/weak_canonical_string_table_test: Pass, Slow # This test can take a longer time to complete.
-
 [ $compiler == app_jitk ]
 dart/snapshot_version_test: RuntimeError
 dart_2/snapshot_version_test: RuntimeError
@@ -198,6 +166,38 @@ dart_2/reachability_test: SkipByDesign # Developer API not supported in product
 [ $nnbd == legacy ]
 dart/*: SkipByDesign # Migrated tests are not supposed to run on non-NNBD bots.
 
+[ $sanitizer == asan ]
+dart/transferable_throws_oom_test: SkipByDesign # This test tries to allocate too much memory on purpose. Still dartbug.com/37188
+dart_2/transferable_throws_oom_test: SkipByDesign # This test tries to allocate too much memory on purpose. Still dartbug.com/37188
+
+[ $sanitizer == tsan ]
+dart/analyze_snapshot_binary_test: SkipSlow
+dart/appjit_cha_deopt_test: SkipSlow
+dart/gc/fragmentation*: Skip # Uses too much memory with TSAN overhead and kills bot
+dart/gc/out_of_memory*: Skip # Uses too much memory with TSAN overhead and kills bot
+dart/gc/scavenger_abort_test: SkipSlow
+dart/hash_map_probes_limit_test: SkipSlow # Test includes large program compilation.
+dart/regress_40462_test: SkipSlow
+dart/regress_40753_test: Skip # This test crashes on the bot, but not locally, and infrastructure repeatedly fails to locate its coredump.
+dart/regress_48523_test: Pass, Slow
+dart/trigger_gc_in_native_test: Skip # This test crashes on the bot, but not locally, and infrastructure repeatedly fails to locate its coredump.
+dart/unobfuscated_static_symbols_test: Pass, Slow # Test includes creating several snapshots in both ELF and assembly modes.
+dart/use_strip_flag_test: Pass, Slow # This test can take a longer time to complete.
+dart/v8_snapshot_profile_writer_test: SkipSlow
+dart/weak_canonical_string_table_test: Pass, Slow # This test can take a longer time to complete.
+dart_2/analyze_snapshot_binary_test: SkipSlow
+dart_2/appjit_cha_deopt_test: SkipSlow
+dart_2/gc/fragmentation*: Skip # Uses too much memory with TSAN overhead and kills bot
+dart_2/gc/out_of_memory*: Skip # Uses too much memory with TSAN overhead and kills bot
+dart_2/gc/scavenger_abort_test: SkipSlow
+dart_2/hash_map_probes_limit_test: SkipSlow # Test includes large program compilation.
+dart_2/regress_40462_test: SkipSlow
+dart_2/regress_40753_test: Skip # This test crashes on the bot, but not locally, and infrastructure repeatedly fails to locate its coredump.
+dart_2/trigger_gc_in_native_test: Skip # This test crashes on the bot, but not locally, and infrastructure repeatedly fails to locate its coredump.
+dart_2/use_strip_flag_test: Pass, Slow # This test can take a longer time to complete.
+dart_2/v8_snapshot_profile_writer_test: SkipSlow
+dart_2/weak_canonical_string_table_test: Pass, Slow # This test can take a longer time to complete.
+
 [ $system == android ]
 dart/isolates/dart_api_create_lightweight_isolate_test: SkipByDesign # On android this test does not work due to not being able to identify library uri.
 dart/sdk_hash_test: SkipByDesign # The test doesn't know location of cross-platform gen_snapshot
@@ -395,14 +395,14 @@ dart/isolates/fast_object_copy_test*: SkipSlow
 dart_2/awaiter_stacks/async_throws_stack_lazy_non_symbolic_test: Pass, Slow
 dart_2/isolates/fast_object_copy_test*: SkipSlow
 
-[ $compiler == dartkp && ($builder_tag == tsan || $simulator) ]
-dart/regress_45898_test: Pass, Slow
-dart_2/regress_45898_test: Pass, Slow
-
 [ $compiler == dartkp && ($runtime == dart_precompiled || $runtime == vm) ]
 dart/spawn_shutdown_test: SkipSlow
 dart_2/spawn_shutdown_test: SkipSlow
 
+[ $compiler == dartkp && ($sanitizer == tsan || $simulator) ]
+dart/regress_45898_test: Pass, Slow
+dart_2/regress_45898_test: Pass, Slow
+
 [ $mode == debug && $system == windows ]
 dart/spawn_shutdown_test: Skip # Flaky crashes unable to start thread; likely low memory on the bot.
 dart_2/spawn_shutdown_test: Skip # Flaky crashes unable to start thread; likely low memory on the bot.
diff --git a/samples/samples.status b/samples/samples.status
index 1c074b410dc..0cea15b080b 100644
--- a/samples/samples.status
+++ b/samples/samples.status
@@ -2,7 +2,7 @@
 # for details. All rights reserved. Use of this source code is governed by a
 # BSD-style license that can be found in the LICENSE file.
 
-[ $builder_tag == asan ]
+[ $sanitizer == asan ]
 ffi/samples_test: SkipByDesign # FFI skips, see ffi.status
 
 [ $simulator ]
diff --git a/tests/ffi/ffi.status b/tests/ffi/ffi.status
index 681c78929cc..3b909e70cab 100644
--- a/tests/ffi/ffi.status
+++ b/tests/ffi/ffi.status
@@ -73,13 +73,10 @@ vmspecific_regress_37511_test: SkipByDesign # Symbols are not exposed on purpose
 vmspecific_regress_37780_test: SkipByDesign # Symbols are not exposed on purpose and are not linked in Windows Precompiled. dartbug.com/40579
 vmspecific_regress_51794_test: SkipByDesign # Symbols are not exposed on purpose and are not linked in Windows Precompiled. dartbug.com/40579
 
-[ $builder_tag == asan || $builder_tag == msan || $builder_tag == tsan ]
-data_not_asan_test: SkipByDesign # This test tries to allocate too much memory on purpose.
-
 # These tests trigger and catch an abort (intentionally) and terminate the VM.
 # They're incompatible with ASAN because not all memory is freed when aborting and
 # with AppJit because the abort the VM before it can generate a snapshot.
-[ $builder_tag == asan || $compiler == app_jitk ]
+[ $compiler == app_jitk || $sanitizer == asan ]
 vmspecific_function_callbacks_exit_test: SkipByDesign
 
 [ $compiler == dart2analyzer || $compiler == fasta ]
@@ -96,3 +93,6 @@ abi_specific_int_incomplete_jit_test: SkipByDesign # Only intended to run in JIT
 
 [ $compiler != dartkp || $arch == arm64 && $system == fuchsia ]
 abi_specific_int_incomplete_aot_test: SkipByDesign # Only intended to run in AOT mode.
+
+[ $sanitizer == asan || $sanitizer == msan || $sanitizer == tsan ]
+data_not_asan_test: SkipByDesign # This test tries to allocate too much memory on purpose.
diff --git a/tests/ffi_2/ffi_2.status b/tests/ffi_2/ffi_2.status
index 5b42ec0736a..26a9238776e 100644
--- a/tests/ffi_2/ffi_2.status
+++ b/tests/ffi_2/ffi_2.status
@@ -60,13 +60,10 @@ vmspecific_handle_test: SkipByDesign # Symbols are not exposed on purpose and ar
 [ $system != android && $system != linux && $system != macos && $system != windows ]
 *: Skip # FFI not yet supported on other OSes.
 
-[ $builder_tag == asan || $builder_tag == msan || $builder_tag == tsan ]
-data_not_asan_test: SkipByDesign # This test tries to allocate too much memory on purpose.
-
 # These tests trigger and catch an abort (intentionally) and terminate the VM.
 # They're incompatible with ASAN because not all memory is freed when aborting and
 # with AppJit because the abort the VM before it can generate a snapshot.
-[ $builder_tag == asan || $compiler == app_jitk ]
+[ $compiler == app_jitk || $sanitizer == asan ]
 vmspecific_function_callbacks_exit_test: SkipByDesign
 
 [ $compiler == dart2analyzer || $compiler == fasta ]
@@ -77,3 +74,6 @@ abi_specific_int_incomplete_jit_test: SkipByDesign # Only intended to run in JIT
 
 [ $compiler != dartkp || $arch == arm64 && $system == fuchsia ]
 abi_specific_int_incomplete_aot_test: SkipByDesign # Only intended to run in AOT mode.
+
+[ $sanitizer == asan || $sanitizer == msan || $sanitizer == tsan ]
+data_not_asan_test: SkipByDesign # This test tries to allocate too much memory on purpose.
diff --git a/tests/standalone/standalone.status b/tests/standalone/standalone.status
index a0f66e072a7..7e0de639f21 100644
--- a/tests/standalone/standalone.status
+++ b/tests/standalone/standalone.status
@@ -14,9 +14,6 @@ io/non_utf8_link_test: Skip # Issue 33519. Temp files causing bots to go purple.
 packages_file_test: Skip # Issue 26715
 packages_file_test/none: Skip # contains no tests.
 
-[ $builder_tag == asan ]
-io/process_detached_test: Slow, Pass
-
 [ $builder_tag == dwarf ]
 io/socket_connect_stacktrace_test: SkipByDesign # Assumes stacktrace can be inspected directly, without decoding
 stack_trace/full1_test: SkipByDesign # Relies on symbolic stack traces.
@@ -78,6 +75,9 @@ io/wait_for_event_zone_test: SkipByDesign # Uses mirrors.
 io/wait_for_test: SkipByDesign # Uses mirrors.
 verbose_gc_to_bmu_test: Skip # Attempts to spawn dart using Platform.executable
 
+[ $sanitizer == asan ]
+io/process_detached_test: Slow, Pass
+
 [ $system != macos ]
 io/https_connection_closed_during_handshake_test: SkipByDesign # long_ssl_cert_evaluation needed for long handshake is only supported on mac.
 io/https_nonblocking_trust_evaluation_test: SkipByDesign
diff --git a/tests/standalone/standalone_kernel.status b/tests/standalone/standalone_kernel.status
index b0002144eda..ca3830c368d 100644
--- a/tests/standalone/standalone_kernel.status
+++ b/tests/standalone/standalone_kernel.status
@@ -98,11 +98,11 @@ io/web_socket_test: Skip # Flaky.
 map_insert_remove_oom_test: Skip # Heap limit too low.
 no_support_debugger_test: Skip # kernel-service snapshot not compatible with flag disabled
 
-[ $builder_tag == asan || $builder_tag == lsan || $builder_tag == msan || $builder_tag == tsan ]
-regress_52715_test/measure: Skip # Shadow memory and scudo quarantine interfere with measuring RSS
-
 [ $builder_tag == crossword || $compiler != dartk && $compiler != dartkp || $compiler == dartkp && $system == windows ]
 entrypoints_verification_test: SkipByDesign # Requires VM to run. Cannot run in precompiled Windows because the DLL is linked against dart.exe instead of dart_precompiled_runtime.exe. Cannot run in cross-word environment as native extension is not built.
 
 [ $compiler != dartk || $runtime != vm ]
 check_for_aot_snapshot_jit_test: SkipByDesign # Test relies on paths, requires JIT test environment.
+
+[ $sanitizer == asan || $sanitizer == lsan || $sanitizer == msan || $sanitizer == tsan ]
+regress_52715_test/measure: Skip # Shadow memory and scudo quarantine interfere with measuring RSS
diff --git a/tests/standalone_2/standalone_2.status b/tests/standalone_2/standalone_2.status
index fc0adec89de..4edeb994a2f 100644
--- a/tests/standalone_2/standalone_2.status
+++ b/tests/standalone_2/standalone_2.status
@@ -14,9 +14,6 @@ io/non_utf8_link_test: Skip # Issue 33519. Temp files causing bots to go purple.
 packages_file_test: Skip # Issue 26715
 packages_file_test/none: Skip # contains no tests.
 
-[ $builder_tag == asan ]
-io/process_detached_test: Slow, Pass
-
 [ $builder_tag == dwarf ]
 io/socket_connect_stacktrace_test: SkipByDesign # Assumes stacktrace can be inspected directly, without decoding
 
@@ -71,6 +68,9 @@ io/wait_for_event_zone_test: SkipByDesign # Uses mirrors.
 io/wait_for_test: SkipByDesign # Uses mirrors.
 verbose_gc_to_bmu_test: Skip # Attempts to spawn dart using Platform.executable
 
+[ $sanitizer == asan ]
+io/process_detached_test: Slow, Pass
+
 # Fuchsia test runner doesn't support multi-tests yet.
 [ $system == fuchsia ]
 deny_listed_test: Skip
diff --git a/tools/bots/test_matrix.json b/tools/bots/test_matrix.json
index 978e2d61348..048fe1245ab 100644
--- a/tools/bots/test_matrix.json
+++ b/tools/bots/test_matrix.json
@@ -392,65 +392,16 @@
         "use-elf": true
       }
     },
-    "vm-asan-(linux|mac)-(debug|product|release)-(ia32|x64|simarm|simarm64|simriscv32|simriscv64)": {
-      "options": {
-        "builder-tag": "asan",
-        "timeout": 240
-      }
-    },
-    "vm-lsan-(linux|mac)-(debug|product|release)-(ia32|x64|simarm|simarm64|simriscv32|simriscv64)": {
-      "options": {
-        "builder-tag": "lsan",
-        "timeout": 240
-      }
-    },
-    "vm-msan-linux-(debug|product|release)-(x64|simarm64|simriscv64)": {
-      "options": {
-        "builder-tag": "msan",
-        "timeout": 240
-      }
-    },
-    "vm-tsan-(linux|mac)-(debug|product|release)-(x64|simarm64|simriscv64)": {
-      "options": {
-        "builder-tag": "tsan",
-        "timeout": 240
-      }
-    },
-    "vm-ubsan-(linux|mac)-(debug|product|release)-(ia32|x64|simarm|simarm64|simriscv32|simriscv64)": {
-      "options": {
-        "builder-tag": "ubsan",
-        "timeout": 240
-      }
-    },
-    "vm-aot-asan-(linux|mac)-(debug|product|release)-(x64|simarm|simarm64|simriscv32|simriscv64)": {
-      "options": {
-        "builder-tag": "asan"
-      }
-    },
-    "vm-aot-lsan-(linux|mac)-(debug|product|release)-(x64|simarm|simarm64|simriscv32|simriscv64)": {
-      "options": {
-        "builder-tag": "lsan",
-        "timeout": 240
-      }
-    },
-    "vm-aot-msan-linux-(debug|product|release)-(x64|simarm64|simriscv64)": {
-      "options": {
-        "builder-tag": "msan",
-        "timeout": 240
-      }
-    },
-    "vm-aot-tsan-(linux|mac)-(debug|product|release)-(x64|simarm64|simriscv64)": {
-      "options": {
-        "builder-tag": "tsan",
-        "timeout": 240
-      }
-    },
-    "vm-aot-ubsan-(linux|mac)-(debug|product|release)-(x64|simarm|simarm64|simriscv32|simriscv64)": {
-      "options": {
-        "builder-tag": "ubsan",
-        "timeout": 240
-      }
-    },
+    "vm-asan-(linux|mac)-(debug|product|release)-(ia32|x64|simarm|simarm64|simriscv32|simriscv64)": {},
+    "vm-lsan-(linux|mac)-(debug|product|release)-(ia32|x64|simarm|simarm64|simriscv32|simriscv64)": {},
+    "vm-msan-linux-(debug|product|release)-(x64|simarm64|simriscv64)": {},
+    "vm-tsan-(linux|mac)-(debug|product|release)-(x64|simarm64|simriscv64)": {},
+    "vm-ubsan-(linux|mac)-(debug|product|release)-(ia32|x64|simarm|simarm64|simriscv32|simriscv64)": {},
+    "vm-aot-asan-(linux|mac)-(debug|product|release)-(x64|simarm|simarm64|simriscv32|simriscv64)": {},
+    "vm-aot-lsan-(linux|mac)-(debug|product|release)-(x64|simarm|simarm64|simriscv32|simriscv64)": {},
+    "vm-aot-msan-linux-(debug|product|release)-(x64|simarm64|simriscv64)": {},
+    "vm-aot-tsan-(linux|mac)-(debug|product|release)-(x64|simarm64|simriscv64)": {},
+    "vm-aot-ubsan-(linux|mac)-(debug|product|release)-(x64|simarm|simarm64|simriscv32|simriscv64)": {},
     "dart2js-(linux|win)-chrome": {
       "options": {
         "use-sdk": true