diff --git a/tests/lib_2/lib_2.status b/tests/lib_2/lib_2.status
index 157c2d48d16..262b9c62622 100644
--- a/tests/lib_2/lib_2.status
+++ b/tests/lib_2/lib_2.status
@@ -16,42 +16,6 @@ isolate/issue_24243_parent_isolate_test: Skip # Requires checked mode
 [ $runtime == chrome ]
 html/element_animate_test/timing_dict: RuntimeError # Issue 26730
 
-[ $runtime == dart_precompiled ]
-isolate/count_test: Skip # Isolate.spawnUri
-isolate/cross_isolate_message_test: Skip # Isolate.spawnUri
-isolate/deferred_in_isolate2_test: Skip # Isolate.spawnUri
-isolate/deferred_in_isolate_test: Skip # Isolate.spawnUri
-isolate/error_at_spawnuri_test: Skip # Isolate.spawnUri
-isolate/error_exit_at_spawnuri_test: Skip # Isolate.spawnUri
-isolate/exit_at_spawnuri_test: Skip # Isolate.spawnUri
-isolate/illegal_msg_function_test: Skip # Isolate.spawnUri
-isolate/illegal_msg_mirror_test: Skip # Isolate.spawnUri
-isolate/isolate_complex_messages_test: Skip # Isolate.spawnUri
-isolate/issue_21398_parent_isolate1_test: Skip # Isolate.spawnUri
-isolate/issue_21398_parent_isolate_test: Skip # Isolate.spawnUri
-isolate/issue_24243_parent_isolate_test: Skip # Isolate.spawnUri
-isolate/issue_6610_test: Skip # Isolate.spawnUri
-isolate/mandel_isolate_test: Skip # Isolate.spawnUri
-isolate/message2_test: Skip # Isolate.spawnUri
-isolate/message_test: Skip # Isolate.spawnUri
-isolate/mint_maker_test: Skip # Isolate.spawnUri
-isolate/nested_spawn2_test: Skip # Isolate.spawnUri
-isolate/nested_spawn_test: Skip # Isolate.spawnUri
-isolate/raw_port_test: Skip # Isolate.spawnUri
-isolate/request_reply_test: Skip # Isolate.spawnUri
-isolate/spawn_function_custom_class_test: Skip # Isolate.spawnUri
-isolate/spawn_function_test: Skip # Isolate.spawnUri
-isolate/spawn_uri_exported_main_test: Skip # Isolate.spawnUri
-isolate/spawn_uri_missing_from_isolate_test: Skip # Isolate.spawnUri
-isolate/spawn_uri_missing_test: Skip # Isolate.spawnUri
-isolate/spawn_uri_multi_test: Skip # Isolate.spawnUri
-isolate/spawn_uri_nested_vm_test: Skip # Isolate.spawnUri
-isolate/spawn_uri_test: Skip # Isolate.spawnUri
-isolate/spawn_uri_vm_test: Skip # Isolate.spawnUri
-isolate/stacktrace_message_test: Skip # Isolate.spawnUri
-isolate/static_function_test: Skip # Isolate.spawnUri
-isolate/unresolved_ports_test: Skip # Isolate.spawnUri
-
 [ $runtime == ff ]
 convert/streamed_conversion_utf8_decode_test: Pass, Slow # Issue 12029
 mirrors/mirrors_reader_test: Timeout, Slow, RuntimeError # Issue 16589
@@ -190,6 +154,46 @@ isolate/vm_rehash_test: SkipByDesign
 [ !$preview_dart_2 && ($runtime == dart_precompiled || $runtime == vm) ]
 *: SkipByDesign # Deprecating all Dart1 modes of execution
 
+# It makes no sense to run any test that uses spawnURI under the simulator
+# as that would involve running CFE (the front end) in simulator mode
+# to compile the URI file specified in spawnURI code.
+# These Isolate tests that use spawnURI are hence skipped on purpose.
+[ ($arch == simarm || $arch == simarm64 || $arch == simdbc64) && ($runtime == dart_precompiled || $runtime == vm) ]
+isolate/count_test: Skip # Isolate.spawnUri
+isolate/cross_isolate_message_test: Skip # Isolate.spawnUri
+isolate/deferred_in_isolate2_test: Skip # Isolate.spawnUri
+isolate/deferred_in_isolate_test: Skip # Isolate.spawnUri
+isolate/error_at_spawnuri_test: Skip # Isolate.spawnUri
+isolate/error_exit_at_spawnuri_test: Skip # Isolate.spawnUri
+isolate/exit_at_spawnuri_test: Skip # Isolate.spawnUri
+isolate/illegal_msg_function_test: Skip # Isolate.spawnUri
+isolate/illegal_msg_mirror_test: Skip # Isolate.spawnUri
+isolate/isolate_complex_messages_test: Skip # Isolate.spawnUri
+isolate/issue_21398_parent_isolate1_test: Skip # Isolate.spawnUri
+isolate/issue_21398_parent_isolate_test: Skip # Isolate.spawnUri
+isolate/issue_24243_parent_isolate_test: Skip # Isolate.spawnUri
+isolate/issue_6610_test: Skip # Isolate.spawnUri
+isolate/mandel_isolate_test: Skip # Isolate.spawnUri
+isolate/message2_test: Skip # Isolate.spawnUri
+isolate/message_test: Skip # Isolate.spawnUri
+isolate/mint_maker_test: Skip # Isolate.spawnUri
+isolate/nested_spawn2_test: Skip # Isolate.spawnUri
+isolate/nested_spawn_test: Skip # Isolate.spawnUri
+isolate/raw_port_test: Skip # Isolate.spawnUri
+isolate/request_reply_test: Skip # Isolate.spawnUri
+isolate/spawn_function_custom_class_test: Skip # Isolate.spawnUri
+isolate/spawn_function_test: Skip # Isolate.spawnUri
+isolate/spawn_uri_exported_main_test: Skip # Isolate.spawnUri
+isolate/spawn_uri_missing_from_isolate_test: Skip # Isolate.spawnUri
+isolate/spawn_uri_missing_test: Skip # Isolate.spawnUri
+isolate/spawn_uri_multi_test: Skip # Isolate.spawnUri
+isolate/spawn_uri_nested_vm_test: Skip # Isolate.spawnUri
+isolate/spawn_uri_test: Skip # Isolate.spawnUri
+isolate/spawn_uri_vm_test: Skip # Isolate.spawnUri
+isolate/stacktrace_message_test: Skip # Isolate.spawnUri
+isolate/static_function_test: Skip # Isolate.spawnUri
+isolate/unresolved_ports_test: Skip # Isolate.spawnUri
+
 [ $arch == simarm || $arch == simarmv5te || $arch == simarmv6 ]
 convert/utf85_test: Skip # Pass, Slow Issue 12644.
 
diff --git a/tests/lib_2/lib_2_kernel.status b/tests/lib_2/lib_2_kernel.status
index c52f96f8ee2..2c6f12b81e9 100644
--- a/tests/lib_2/lib_2_kernel.status
+++ b/tests/lib_2/lib_2_kernel.status
@@ -48,15 +48,9 @@ mirrors/metadata_allowed_values_test/14: MissingCompileTimeError
 mirrors/redirecting_factory_test/01: CompileTimeError # Issue 34714
 mirrors/redirecting_factory_test/none: CompileTimeError # Issue 34714
 
-[ $arch == simdbc64 && $mode == debug && $runtime == vm && ($compiler == dartk || $compiler == dartkb) ]
-isolate/isolate_complex_messages_test: Crash # http://dartbug.com/33128
-
 [ $arch == simdbc64 && $hot_reload_rollback ]
 convert/streamed_conversion_json_utf8_decode_test: SkipSlow # Uses --verify_before_gc --verify_after_gc --old_gen_growth_rate=1 flags
 
-[ $arch == simdbc64 && ($compiler == dartk || $compiler == dartkb) ]
-isolate/issue_24243_parent_isolate_test: RuntimeError # dartbug.com/35373
-
 [ $arch == x64 && $builder_tag == asan && $compiler == dartk ]
 mirrors/dynamic_load_test: Fail # Memory leak (issue 34724)
 
@@ -207,8 +201,6 @@ isolate/pause_test: Skip # Timeout
 # are to be triaged.  Isolate tests are skipped on purpose due to the usage of
 # batch mode.
 [ ($arch == simarm || $arch == simarm64 || $arch == simdbc64) && ($compiler == dartk || $compiler == dartkb) ]
-isolate/mandel_isolate_test: Pass, Timeout
-isolate/nested_spawn2_test: Pass, RuntimeError # RuntimeError caused by timeout
 mirrors/library_uri_io_test: RuntimeError # Please triage.
 
 [ ($compiler == dartk || $compiler == dartkb) && ($hot_reload || $hot_reload_rollback) ]