diff --git a/tests/co19/co19-dart2js.status b/tests/co19/co19-dart2js.status
index 1760bdc7b6e..ea42fa10fbe 100644
--- a/tests/co19/co19-dart2js.status
+++ b/tests/co19/co19-dart2js.status
@@ -92,6 +92,9 @@ LibTest/typed_data/ByteData/setUint64_A02_t02: SkipByDesign # 64-bit int not sup
 LibTest/typed_data/Int64List/*: SkipByDesign # Int64List not supported on the web
 LibTest/typed_data/Uint64List/*: SkipByDesign # Uint64List not supported on the web
 
+[ $compiler == dart2js && $runtime == chrome ]
+LibTest/html/Window/animationFrame_A01_t01: SkipByDesign # Issue #53985: requestAnimationFrame is not executed on Chrome inactive tabs
+
 [ $compiler == dart2js && $runtime == d8 ]
 LibTest/html/*: SkipByDesign # d8 is not a browser
 
@@ -117,5 +120,6 @@ LibTest/core/List/List_class_A01_t05: SkipSlow # slow babeljs transformation
 LibTest/core/List/List_class_A01_t06: SkipSlow # slow babeljs transformation
 
 [ $compiler == dart2js && $runtime == safari ]
+LibTest/html/Element/isContentEditable_A01_t01: Skip # 98% fails in Safari, evades flake detection https://github.com/dart-lang/sdk/issues/50718
 LibTest/html/Element/isContentEditable_A02_t01: Skip # evades flake detection https://github.com/dart-lang/sdk/issues/50718
 LibTest/html/IFrameElement/isContentEditable_A01_t01: Skip # evades flake detection https://github.com/dart-lang/sdk/issues/50718
diff --git a/tests/co19/co19-dartdevc.status b/tests/co19/co19-dartdevc.status
index 0871dac9a73..4e47b91c3eb 100644
--- a/tests/co19/co19-dartdevc.status
+++ b/tests/co19/co19-dartdevc.status
@@ -89,3 +89,6 @@ LibTest/typed_data/ByteData/setUint64_A02_t01: SkipByDesign # 64-bit int not sup
 LibTest/typed_data/ByteData/setUint64_A02_t02: SkipByDesign # 64-bit int not supported on the web
 LibTest/typed_data/Int64List/*: SkipByDesign # Int64List not supported on the web
 LibTest/typed_data/Uint64List/*: SkipByDesign # Uint64List not supported on the web
+
+[ $compiler == ddc && $runtime == chrome ]
+LibTest/html/Window/animationFrame_A01_t01: SkipByDesign # Issue #53985: requestAnimationFrame is not executed on Chrome inactive tabs
diff --git a/tests/co19_2/co19_2-dart2js.status b/tests/co19_2/co19_2-dart2js.status
index b027c8b66b9..5370dbfe894 100644
--- a/tests/co19_2/co19_2-dart2js.status
+++ b/tests/co19_2/co19_2-dart2js.status
@@ -56,6 +56,11 @@ LibTest/typed_data/ByteData/setUint64_A02_t02: SkipByDesign # 64-bit int not sup
 LibTest/typed_data/Int64List/*: SkipByDesign # Int64List not supported on the web
 LibTest/typed_data/Uint64List/*: SkipByDesign # Uint64List not supported on the web
 
+[ $compiler == dart2js && $runtime == chrome ]
+LibTest/html/Window/animationFrame_A01_t01: SkipByDesign # Issue #53985: requestAnimationFrame is not executed on Chrome inactive tabs
+co19_2/LibTest/html/IFrameElement/blur_A01_t01: SkipByDesign # 62% flaky, unexplained, passes consistently in co19 suite (just flakes in co19_2)
+co19_2/LibTest/html/IFrameElement/focus_A01_t01: SkipByDesign # 80% flaky, unexplained, passes consistently in co19 suite (just flakes in co19_2)
+
 [ $compiler == dart2js && $runtime == d8 ]
 LibTest/html/*: SkipByDesign # d8 is not a browser
 
diff --git a/tests/co19_2/co19_2-dartdevc.status b/tests/co19_2/co19_2-dartdevc.status
index 61809eb5bf6..c3f2d109e25 100644
--- a/tests/co19_2/co19_2-dartdevc.status
+++ b/tests/co19_2/co19_2-dartdevc.status
@@ -124,3 +124,6 @@ LibTest/typed_data/ByteData/setUint64_A02_t01: SkipByDesign # 64-bit int not sup
 LibTest/typed_data/ByteData/setUint64_A02_t02: SkipByDesign # 64-bit int not supported on the web
 LibTest/typed_data/Int64List/*: SkipByDesign # Int64List not supported on the web
 LibTest/typed_data/Uint64List/*: SkipByDesign # Uint64List not supported on the web
+
+[ $compiler == ddc && $runtime == chrome ]
+LibTest/html/Window/animationFrame_A01_t01: SkipByDesign # Issue #53985: requestAnimationFrame is not executed on Chrome inactive tabs
diff --git a/tests/lib/lib_dart2js.status b/tests/lib/lib_dart2js.status
index c1dd3702517..953c14869fe 100644
--- a/tests/lib/lib_dart2js.status
+++ b/tests/lib/lib_dart2js.status
@@ -35,6 +35,9 @@ async/slow_consumer2_test: SkipSlow # Times out. Issue 22050
 convert/streamed_conversion_json_utf8_decode_test: SkipSlow # Times out. Issue 22050
 convert/streamed_conversion_json_utf8_encode_test: SkipSlow # Times out. Issue 22050
 convert/streamed_conversion_utf8_decode_test: SkipSlow # Times out. Issue 22050
+html/canvasrendering/draw_image_video_element_test: SkipByDesign # Issue #53985: video is not played on Chrome inactive tabs
+html/request_animation_frame_test: SkipByDesign # Issue #53985: requestAnimationFrame is not executed on Chrome inactive tabs
+html/transition_event_test: SkipByDesign # Issue #53985: css transitions are not executed on Chrome inactive tabs
 
 [ $compiler == dart2js && $runtime == chromeOnAndroid ]
 html/input_element_datetime_test: Slow, Pass # TODO(dart2js-team): Please triage this failure.
diff --git a/tests/lib/lib_dartdevc.status b/tests/lib/lib_dartdevc.status
index 9ee4c33628a..85c8acefd5d 100644
--- a/tests/lib/lib_dartdevc.status
+++ b/tests/lib/lib_dartdevc.status
@@ -29,7 +29,10 @@ typed_data/int64_list_load_store_test: SkipByDesign # ddc does not support Int64
 typed_data/typed_data_hierarchy_int64_test: SkipByDesign # ddc does not support Int64List
 
 [ $compiler == ddc && $runtime == chrome ]
+html/canvasrendering/draw_image_video_element_test: SkipByDesign # Issue #53985: video is not played on Chrome inactive tabs
 html/js_dispatch_property_test: Skip # Timeout Issue 31030
+html/request_animation_frame_test: SkipByDesign # Issue #53985: requestAnimationFrame is not executed on Chrome inactive tabs
+html/transition_event_test: SkipByDesign # Issue #53985: css transitions are not executed on Chrome inactive tabs
 
 [ $compiler == ddc && $runtime == ff ]
 html/mediadevices_test: SkipByDesign # Not supported on FF, likely requires user-interaction that causes timeout
diff --git a/tests/lib_2/lib_2_dart2js.status b/tests/lib_2/lib_2_dart2js.status
index acfdedc69d5..78fbe2786fc 100644
--- a/tests/lib_2/lib_2_dart2js.status
+++ b/tests/lib_2/lib_2_dart2js.status
@@ -33,6 +33,9 @@ async/slow_consumer2_test: SkipSlow # Times out. Issue 22050
 convert/streamed_conversion_json_utf8_decode_test: SkipSlow # Times out. Issue 22050
 convert/streamed_conversion_json_utf8_encode_test: SkipSlow # Times out. Issue 22050
 convert/streamed_conversion_utf8_decode_test: SkipSlow # Times out. Issue 22050
+html/canvasrendering/draw_image_video_element_test: SkipByDesign # Issue #53985: video is not played on Chrome inactive tabs
+html/request_animation_frame_test: SkipByDesign # Issue #53985: requestAnimationFrame is not executed on Chrome inactive tabs
+html/transition_event_test: SkipByDesign # Issue #53985: css transitions are not executed on Chrome inactive tabs
 
 [ $compiler == dart2js && $runtime == chromeOnAndroid ]
 html/input_element_datetime_test: Slow, Pass # TODO(dart2js-team): Please triage this failure.
@@ -70,7 +73,6 @@ html/interactive_media_test: SkipSlow
 html/mediasource_test: Skip # evades flake detection https://github.com/dart-lang/sdk/issues/50718
 js/js_util/bigint_test: Skip # evades flake detection https://github.com/dart-lang/sdk/issues/50718
 
-
 [ $compiler == dart2js && $checked ]
 convert/utf85_test: Slow, Pass # Issue 12029.
 html/js_function_getter_trust_types/function_test: Skip # --trust-type-annotations incompatible with --checked
diff --git a/tests/lib_2/lib_2_dartdevc.status b/tests/lib_2/lib_2_dartdevc.status
index 713fee1b806..2ea7dd2b71d 100644
--- a/tests/lib_2/lib_2_dartdevc.status
+++ b/tests/lib_2/lib_2_dartdevc.status
@@ -27,7 +27,10 @@ js/js_util/js_prefix_test: SkipByDesign # JS$ prefix not implemented on ddc.
 mirrors/*: SkipByDesign # Mirrors not supported on web in Dart 2.0.
 
 [ $compiler == ddc && $runtime == chrome ]
+html/canvasrendering/draw_image_video_element_test: SkipByDesign # Issue #53985: video is not played on Chrome inactive tabs
 html/js_dispatch_property_test: Skip # Timeout Issue 31030
+html/request_animation_frame_test: SkipByDesign # Issue #53985: requestAnimationFrame is not executed on Chrome inactive tabs
+html/transition_event_test: SkipByDesign # Issue #53985: css transitions are not executed on Chrome inactive tabs
 
 [ $compiler == ddc && $runtime == ff ]
 html/mediadevices_test: SkipByDesign # Not supported on FF, likely requires user-interaction that causes timeout