diff --git a/Misc/NEWS.d/next/Library/2022-07-27-11-35-45.gh-issue-95045.iysT-Q.rst b/Misc/NEWS.d/next/Library/2022-07-27-11-35-45.gh-issue-95045.iysT-Q.rst
new file mode 100644
index 00000000000..d4ab325e036
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-07-27-11-35-45.gh-issue-95045.iysT-Q.rst
@@ -0,0 +1 @@
+Fix GC crash when deallocating ``_lsprof.Profiler`` by untracking it before calling any callbacks. Patch by Kumar Aditya.
diff --git a/Modules/_lsprof.c b/Modules/_lsprof.c
index 0e8432fda01..a0e262bdac2 100644
--- a/Modules/_lsprof.c
+++ b/Modules/_lsprof.c
@@ -747,6 +747,7 @@ profiler_traverse(ProfilerObject *op, visitproc visit, void *arg)
 static void
 profiler_dealloc(ProfilerObject *op)
 {
+    PyObject_GC_UnTrack(op);
     if (op->flags & POF_ENABLED) {
         PyThreadState *tstate = _PyThreadState_GET();
         if (_PyEval_SetProfile(tstate, NULL, NULL) < 0) {