diff --git a/Lib/ipaddress.py b/Lib/ipaddress.py
index e601f6f476e..3f15601e700 100644
--- a/Lib/ipaddress.py
+++ b/Lib/ipaddress.py
@@ -51,8 +51,7 @@ def ip_address(address):
     except (AddressValueError, NetmaskValueError):
         pass
 
-    raise ValueError('%r does not appear to be an IPv4 or IPv6 address' %
-                     address)
+    raise ValueError(f'{address!r} does not appear to be an IPv4 or IPv6 address')
 
 
 def ip_network(address, strict=True):
@@ -81,8 +80,7 @@ def ip_network(address, strict=True):
     except (AddressValueError, NetmaskValueError):
         pass
 
-    raise ValueError('%r does not appear to be an IPv4 or IPv6 network' %
-                     address)
+    raise ValueError(f'{address!r} does not appear to be an IPv4 or IPv6 network')
 
 
 def ip_interface(address):
@@ -116,8 +114,7 @@ def ip_interface(address):
     except (AddressValueError, NetmaskValueError):
         pass
 
-    raise ValueError('%r does not appear to be an IPv4 or IPv6 interface' %
-                     address)
+    raise ValueError(f'{address!r} does not appear to be an IPv4 or IPv6 interface')
 
 
 def v4_int_to_packed(address):
@@ -160,7 +157,7 @@ def _split_optional_netmask(address):
     """Helper to split the netmask and raise AddressValueError if needed"""
     addr = str(address).split('/')
     if len(addr) > 2:
-        raise AddressValueError("Only one '/' permitted in %r" % address)
+        raise AddressValueError(f"Only one '/' permitted in {address!r}")
     return addr
 
 
@@ -1304,7 +1301,7 @@ def __init__(self, address):
         # which converts into a formatted IP string.
         addr_str = str(address)
         if '/' in addr_str:
-            raise AddressValueError("Unexpected '/' in %r" % address)
+            raise AddressValueError(f"Unexpected '/' in {address!r}")
         self._ip = self._ip_int_from_string(addr_str)
 
     @property
@@ -1913,7 +1910,7 @@ def __init__(self, address):
         # which converts into a formatted IP string.
         addr_str = str(address)
         if '/' in addr_str:
-            raise AddressValueError("Unexpected '/' in %r" % address)
+            raise AddressValueError(f"Unexpected '/' in {address!r}")
         addr_str, self._scope_id = self._split_scope_id(addr_str)
 
         self._ip = self._ip_int_from_string(addr_str)
diff --git a/Lib/test/test_ipaddress.py b/Lib/test/test_ipaddress.py
index b0605f0be04..e5162e86cb5 100644
--- a/Lib/test/test_ipaddress.py
+++ b/Lib/test/test_ipaddress.py
@@ -1132,6 +1132,14 @@ def testIPv4Tuple(self):
         self.assertEqual(ipaddress.IPv4Interface((3221225985, 24)),
                          ipaddress.IPv4Interface('192.0.2.1/24'))
 
+        # Invalid netmask
+        with self.assertRaises(ValueError):
+            ipaddress.IPv4Network(('192.0.2.1', '255.255.255.255.0'))
+
+        # Invalid netmask using factory
+        with self.assertRaises(ValueError):
+            ipaddress.ip_network(('192.0.2.1', '255.255.255.255.0'))
+
     # issue #16531: constructing IPv6Network from an (address, mask) tuple
     def testIPv6Tuple(self):
         # /128
@@ -1191,6 +1199,14 @@ def testIPv6Tuple(self):
             ipaddress.IPv6Network((ip_scoped, 96))
         # strict=False and host bits set
 
+        # Invalid netmask
+        with self.assertRaises(ValueError):
+            ipaddress.IPv6Network(('2001:db8::1', '255.255.255.0'))
+
+        # Invalid netmask using factory
+        with self.assertRaises(ValueError):
+            ipaddress.ip_network(('2001:db8::1', '255.255.255.0'))
+
     # issue57
     def testAddressIntMath(self):
         self.assertEqual(ipaddress.IPv4Address('1.1.1.1') + 255,
diff --git a/Misc/NEWS.d/next/Library/2022-01-17-16-53-30.bpo-46415.6wSYg-.rst b/Misc/NEWS.d/next/Library/2022-01-17-16-53-30.bpo-46415.6wSYg-.rst
new file mode 100644
index 00000000000..016d6656041
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-01-17-16-53-30.bpo-46415.6wSYg-.rst
@@ -0,0 +1,2 @@
+Fix ipaddress.ip_{address,interface,network} raising TypeError instead of
+ValueError if given invalid tuple as address parameter.