diff --git a/Doc/using/configure.rst b/Doc/using/configure.rst
index 4e50e73a11b..ef770d7747c 100644
--- a/Doc/using/configure.rst
+++ b/Doc/using/configure.rst
@@ -191,7 +191,8 @@ Performance options
 -------------------
 
 Configuring Python using ``--enable-optimizations --with-lto`` (PGO + LTO) is
-recommended for best performance.
+recommended for best performance. The experimental ``--enable-bolt`` flag can
+also be used to improve performance.
 
 .. cmdoption:: --enable-optimizations
 
@@ -231,6 +232,24 @@ recommended for best performance.
    .. versionadded:: 3.11
       To use ThinLTO feature, use ``--with-lto=thin`` on Clang.
 
+.. cmdoption:: --enable-bolt
+
+   Enable usage of the `BOLT post-link binary optimizer
+   <https://github.com/llvm/llvm-project/tree/main/bolt>` (disabled by
+   default).
+
+   BOLT is part of the LLVM project but is not always included in their binary
+   distributions. This flag requires that ``llvm-bolt`` and ``merge-fdata``
+   are available.
+
+   BOLT is still a fairly new project so this flag should be considered
+   experimental for now. Because this tool operates on machine code its success
+   is dependent on a combination of the build environment + the other
+   optimization configure args + the CPU architecture, and not all combinations
+   are supported.
+
+   .. versionadded:: 3.12
+
 .. cmdoption:: --with-computed-gotos
 
    Enable computed gotos in evaluation loop (enabled by default on supported
diff --git a/Doc/whatsnew/3.12.rst b/Doc/whatsnew/3.12.rst
index 9689d9df9df..f9fa8ac3123 100644
--- a/Doc/whatsnew/3.12.rst
+++ b/Doc/whatsnew/3.12.rst
@@ -133,6 +133,10 @@ Optimizations
   It reduces object size by 8 or 16 bytes on 64bit platform. (:pep:`623`)
   (Contributed by Inada Naoki in :gh:`92536`.)
 
+* Added experimental support for using the BOLT binary optimizer in the build
+  process, which improves performance by 1-5%.
+  (Contributed by Kevin Modzelewski in :gh:`90536`.)
+
 
 CPython bytecode changes
 ========================
diff --git a/Makefile.pre.in b/Makefile.pre.in
index c647853c223..ae7735cf69a 100644
--- a/Makefile.pre.in
+++ b/Makefile.pre.in
@@ -640,6 +640,16 @@ profile-opt: profile-run-stamp
 	-rm -f profile-clean-stamp
 	$(MAKE) @DEF_MAKE_RULE@ CFLAGS_NODIST="$(CFLAGS_NODIST) $(PGO_PROF_USE_FLAG)" LDFLAGS_NODIST="$(LDFLAGS_NODIST)"
 
+bolt-opt: @PREBOLT_RULE@
+	rm -f *.fdata
+	@LLVM_BOLT@ ./$(BUILDPYTHON) -instrument -instrumentation-file-append-pid -instrumentation-file=$(abspath $(BUILDPYTHON).bolt) -o $(BUILDPYTHON).bolt_inst
+	./$(BUILDPYTHON).bolt_inst $(PROFILE_TASK) || true
+	@MERGE_FDATA@ $(BUILDPYTHON).*.fdata > $(BUILDPYTHON).fdata
+	@LLVM_BOLT@ ./$(BUILDPYTHON) -o $(BUILDPYTHON).bolt -data=$(BUILDPYTHON).fdata -update-debug-sections -reorder-blocks=ext-tsp -reorder-functions=hfsort+ -split-functions=3 -icf=1 -inline-all -split-eh -reorder-functions-use-hot-size -peepholes=all -jump-tables=aggressive -inline-ap -indirect-call-promotion=all -dyno-stats -use-gnu-stack -frame-opt=hot
+	rm -f *.fdata
+	rm -f $(BUILDPYTHON).bolt_inst
+	mv $(BUILDPYTHON).bolt $(BUILDPYTHON)
+
 # Compile and run with gcov
 .PHONY=coverage coverage-lcov coverage-report
 coverage:
diff --git a/Misc/ACKS b/Misc/ACKS
index c1f570acaaf..16a482e40a5 100644
--- a/Misc/ACKS
+++ b/Misc/ACKS
@@ -1212,6 +1212,7 @@ Gideon Mitchell
 Tim Mitchell
 Zubin Mithra
 Florian Mladitsch
+Kevin Modzelewski
 Doug Moen
 Jakub Molinski
 Juliette Monsel
diff --git a/Misc/NEWS.d/next/Build/2022-08-12-13-06-03.gh-issue-90536.qMpF6p.rst b/Misc/NEWS.d/next/Build/2022-08-12-13-06-03.gh-issue-90536.qMpF6p.rst
new file mode 100644
index 00000000000..4605e03915e
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2022-08-12-13-06-03.gh-issue-90536.qMpF6p.rst
@@ -0,0 +1,2 @@
+Use the BOLT post-link optimizer to improve performance, particularly on
+medium-to-large applications.
diff --git a/configure b/configure
index 82b55a3745d..fb3a3c3fc8f 100755
--- a/configure
+++ b/configure
@@ -887,6 +887,9 @@ LLVM_PROF_FILE
 LLVM_PROF_MERGER
 PGO_PROF_USE_FLAG
 PGO_PROF_GEN_FLAG
+MERGE_FDATA
+LLVM_BOLT
+PREBOLT_RULE
 LLVM_AR_FOUND
 LLVM_AR
 PROFILE_TASK
@@ -1049,6 +1052,7 @@ enable_pystats
 with_assertions
 enable_optimizations
 with_lto
+enable_bolt
 with_address_sanitizer
 with_memory_sanitizer
 with_undefined_behavior_sanitizer
@@ -1774,6 +1778,8 @@ Optional Features:
   --enable-pystats        enable internal statistics gathering (default is no)
   --enable-optimizations  enable expensive, stable optimizations (PGO, etc.)
                           (default is no)
+  --enable-bolt           enable usage of the llvm-bolt post-link optimizer
+                          (default is no)
   --enable-loadable-sqlite-extensions
                           support loadable extensions in the sqlite3 module,
                           see Doc/library/sqlite3.rst (default is no)
@@ -7878,6 +7884,261 @@ $as_echo "$as_me: llvm-ar found via xcrun: ${LLVM_AR}" >&6;}
   LDFLAGS_NODIST="$LDFLAGS_NODIST $LTOFLAGS"
 fi
 
+# Enable bolt flags
+Py_BOLT='false'
+{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for --enable-bolt" >&5
+$as_echo_n "checking for --enable-bolt... " >&6; }
+# Check whether --enable-bolt was given.
+if test "${enable_bolt+set}" = set; then :
+  enableval=$enable_bolt;
+if test "$enableval" != no
+then
+  Py_BOLT='true'
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: yes" >&5
+$as_echo "yes" >&6; };
+else
+  Py_BOLT='false'
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5
+$as_echo "no" >&6; };
+fi
+else
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5
+$as_echo "no" >&6; }
+fi
+
+
+
+if test "$Py_BOLT" = 'true' ; then
+  PREBOLT_RULE="${DEF_MAKE_ALL_RULE}"
+  DEF_MAKE_ALL_RULE="bolt-opt"
+  DEF_MAKE_RULE="build_all"
+
+  # These flags are required for bolt to work:
+  CFLAGS_NODIST="$CFLAGS_NODIST -fno-reorder-blocks-and-partition"
+  LDFLAGS_NODIST="$LDFLAGS_NODIST -Wl,--emit-relocs"
+
+  # These flags are required to get good performance from bolt:
+  CFLAGS_NODIST="$CFLAGS_NODIST -fno-pie"
+  # We want to add these no-pie flags to linking executables but not shared libraries:
+  LINKCC="$LINKCC -fno-pie -no-pie"
+  # Designate the DWARF version into 4 since the LLVM-BOLT does not support DWARF5 yet.
+  CFLAGS="$CFLAGS -gdwarf-4"
+  LDFLAGS="$LDFLAGS -gdwarf-4"
+
+  if test -n "$ac_tool_prefix"; then
+  # Extract the first word of "${ac_tool_prefix}llvm-bolt", so it can be a program name with args.
+set dummy ${ac_tool_prefix}llvm-bolt; ac_word=$2
+{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5
+$as_echo_n "checking for $ac_word... " >&6; }
+if ${ac_cv_path_LLVM_BOLT+:} false; then :
+  $as_echo_n "(cached) " >&6
+else
+  case $LLVM_BOLT in
+  [\\/]* | ?:[\\/]*)
+  ac_cv_path_LLVM_BOLT="$LLVM_BOLT" # Let the user override the test with a path.
+  ;;
+  *)
+  as_save_IFS=$IFS; IFS=$PATH_SEPARATOR
+for as_dir in ${llvm_path}
+do
+  IFS=$as_save_IFS
+  test -z "$as_dir" && as_dir=.
+    for ac_exec_ext in '' $ac_executable_extensions; do
+  if as_fn_executable_p "$as_dir/$ac_word$ac_exec_ext"; then
+    ac_cv_path_LLVM_BOLT="$as_dir/$ac_word$ac_exec_ext"
+    $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5
+    break 2
+  fi
+done
+  done
+IFS=$as_save_IFS
+
+  ;;
+esac
+fi
+LLVM_BOLT=$ac_cv_path_LLVM_BOLT
+if test -n "$LLVM_BOLT"; then
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: $LLVM_BOLT" >&5
+$as_echo "$LLVM_BOLT" >&6; }
+else
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5
+$as_echo "no" >&6; }
+fi
+
+
+fi
+if test -z "$ac_cv_path_LLVM_BOLT"; then
+  ac_pt_LLVM_BOLT=$LLVM_BOLT
+  # Extract the first word of "llvm-bolt", so it can be a program name with args.
+set dummy llvm-bolt; ac_word=$2
+{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5
+$as_echo_n "checking for $ac_word... " >&6; }
+if ${ac_cv_path_ac_pt_LLVM_BOLT+:} false; then :
+  $as_echo_n "(cached) " >&6
+else
+  case $ac_pt_LLVM_BOLT in
+  [\\/]* | ?:[\\/]*)
+  ac_cv_path_ac_pt_LLVM_BOLT="$ac_pt_LLVM_BOLT" # Let the user override the test with a path.
+  ;;
+  *)
+  as_save_IFS=$IFS; IFS=$PATH_SEPARATOR
+for as_dir in ${llvm_path}
+do
+  IFS=$as_save_IFS
+  test -z "$as_dir" && as_dir=.
+    for ac_exec_ext in '' $ac_executable_extensions; do
+  if as_fn_executable_p "$as_dir/$ac_word$ac_exec_ext"; then
+    ac_cv_path_ac_pt_LLVM_BOLT="$as_dir/$ac_word$ac_exec_ext"
+    $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5
+    break 2
+  fi
+done
+  done
+IFS=$as_save_IFS
+
+  ;;
+esac
+fi
+ac_pt_LLVM_BOLT=$ac_cv_path_ac_pt_LLVM_BOLT
+if test -n "$ac_pt_LLVM_BOLT"; then
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_pt_LLVM_BOLT" >&5
+$as_echo "$ac_pt_LLVM_BOLT" >&6; }
+else
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5
+$as_echo "no" >&6; }
+fi
+
+  if test "x$ac_pt_LLVM_BOLT" = x; then
+    LLVM_BOLT="''"
+  else
+    case $cross_compiling:$ac_tool_warned in
+yes:)
+{ $as_echo "$as_me:${as_lineno-$LINENO}: WARNING: using cross tools not prefixed with host triplet" >&5
+$as_echo "$as_me: WARNING: using cross tools not prefixed with host triplet" >&2;}
+ac_tool_warned=yes ;;
+esac
+    LLVM_BOLT=$ac_pt_LLVM_BOLT
+  fi
+else
+  LLVM_BOLT="$ac_cv_path_LLVM_BOLT"
+fi
+
+  if test -n "${LLVM_BOLT}" -a -x "${LLVM_BOLT}"
+  then
+    { $as_echo "$as_me:${as_lineno-$LINENO}: result: \"Found llvm-bolt\"" >&5
+$as_echo "\"Found llvm-bolt\"" >&6; }
+  else
+    as_fn_error $? "llvm-bolt is required for a --enable-bolt build but could not be found." "$LINENO" 5
+  fi
+
+
+  if test -n "$ac_tool_prefix"; then
+  # Extract the first word of "${ac_tool_prefix}merge-fdata", so it can be a program name with args.
+set dummy ${ac_tool_prefix}merge-fdata; ac_word=$2
+{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5
+$as_echo_n "checking for $ac_word... " >&6; }
+if ${ac_cv_path_MERGE_FDATA+:} false; then :
+  $as_echo_n "(cached) " >&6
+else
+  case $MERGE_FDATA in
+  [\\/]* | ?:[\\/]*)
+  ac_cv_path_MERGE_FDATA="$MERGE_FDATA" # Let the user override the test with a path.
+  ;;
+  *)
+  as_save_IFS=$IFS; IFS=$PATH_SEPARATOR
+for as_dir in ${llvm_path}
+do
+  IFS=$as_save_IFS
+  test -z "$as_dir" && as_dir=.
+    for ac_exec_ext in '' $ac_executable_extensions; do
+  if as_fn_executable_p "$as_dir/$ac_word$ac_exec_ext"; then
+    ac_cv_path_MERGE_FDATA="$as_dir/$ac_word$ac_exec_ext"
+    $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5
+    break 2
+  fi
+done
+  done
+IFS=$as_save_IFS
+
+  ;;
+esac
+fi
+MERGE_FDATA=$ac_cv_path_MERGE_FDATA
+if test -n "$MERGE_FDATA"; then
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: $MERGE_FDATA" >&5
+$as_echo "$MERGE_FDATA" >&6; }
+else
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5
+$as_echo "no" >&6; }
+fi
+
+
+fi
+if test -z "$ac_cv_path_MERGE_FDATA"; then
+  ac_pt_MERGE_FDATA=$MERGE_FDATA
+  # Extract the first word of "merge-fdata", so it can be a program name with args.
+set dummy merge-fdata; ac_word=$2
+{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for $ac_word" >&5
+$as_echo_n "checking for $ac_word... " >&6; }
+if ${ac_cv_path_ac_pt_MERGE_FDATA+:} false; then :
+  $as_echo_n "(cached) " >&6
+else
+  case $ac_pt_MERGE_FDATA in
+  [\\/]* | ?:[\\/]*)
+  ac_cv_path_ac_pt_MERGE_FDATA="$ac_pt_MERGE_FDATA" # Let the user override the test with a path.
+  ;;
+  *)
+  as_save_IFS=$IFS; IFS=$PATH_SEPARATOR
+for as_dir in ${llvm_path}
+do
+  IFS=$as_save_IFS
+  test -z "$as_dir" && as_dir=.
+    for ac_exec_ext in '' $ac_executable_extensions; do
+  if as_fn_executable_p "$as_dir/$ac_word$ac_exec_ext"; then
+    ac_cv_path_ac_pt_MERGE_FDATA="$as_dir/$ac_word$ac_exec_ext"
+    $as_echo "$as_me:${as_lineno-$LINENO}: found $as_dir/$ac_word$ac_exec_ext" >&5
+    break 2
+  fi
+done
+  done
+IFS=$as_save_IFS
+
+  ;;
+esac
+fi
+ac_pt_MERGE_FDATA=$ac_cv_path_ac_pt_MERGE_FDATA
+if test -n "$ac_pt_MERGE_FDATA"; then
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_pt_MERGE_FDATA" >&5
+$as_echo "$ac_pt_MERGE_FDATA" >&6; }
+else
+  { $as_echo "$as_me:${as_lineno-$LINENO}: result: no" >&5
+$as_echo "no" >&6; }
+fi
+
+  if test "x$ac_pt_MERGE_FDATA" = x; then
+    MERGE_FDATA="''"
+  else
+    case $cross_compiling:$ac_tool_warned in
+yes:)
+{ $as_echo "$as_me:${as_lineno-$LINENO}: WARNING: using cross tools not prefixed with host triplet" >&5
+$as_echo "$as_me: WARNING: using cross tools not prefixed with host triplet" >&2;}
+ac_tool_warned=yes ;;
+esac
+    MERGE_FDATA=$ac_pt_MERGE_FDATA
+  fi
+else
+  MERGE_FDATA="$ac_cv_path_MERGE_FDATA"
+fi
+
+  if test -n "${MERGE_FDATA}" -a -x "${MERGE_FDATA}"
+  then
+    { $as_echo "$as_me:${as_lineno-$LINENO}: result: \"Found merge-fdata\"" >&5
+$as_echo "\"Found merge-fdata\"" >&6; }
+  else
+    as_fn_error $? "merge-fdata is required for a --enable-bolt build but could not be found." "$LINENO" 5
+  fi
+fi
+
 # Enable PGO flags.
 
 
diff --git a/configure.ac b/configure.ac
index 85d9e801183..bab405e6ed3 100644
--- a/configure.ac
+++ b/configure.ac
@@ -1917,6 +1917,59 @@ if test "$Py_LTO" = 'true' ; then
   LDFLAGS_NODIST="$LDFLAGS_NODIST $LTOFLAGS"
 fi
 
+# Enable bolt flags
+Py_BOLT='false'
+AC_MSG_CHECKING(for --enable-bolt)
+AC_ARG_ENABLE(bolt, AS_HELP_STRING(
+                [--enable-bolt],
+                [enable usage of the llvm-bolt post-link optimizer (default is no)]),
+[
+if test "$enableval" != no
+then
+  Py_BOLT='true'
+  AC_MSG_RESULT(yes);
+else
+  Py_BOLT='false'
+  AC_MSG_RESULT(no);
+fi],
+[AC_MSG_RESULT(no)])
+
+AC_SUBST(PREBOLT_RULE)
+if test "$Py_BOLT" = 'true' ; then
+  PREBOLT_RULE="${DEF_MAKE_ALL_RULE}"
+  DEF_MAKE_ALL_RULE="bolt-opt"
+  DEF_MAKE_RULE="build_all"
+
+  # These flags are required for bolt to work:
+  CFLAGS_NODIST="$CFLAGS_NODIST -fno-reorder-blocks-and-partition"
+  LDFLAGS_NODIST="$LDFLAGS_NODIST -Wl,--emit-relocs"
+
+  # These flags are required to get good performance from bolt:
+  CFLAGS_NODIST="$CFLAGS_NODIST -fno-pie"
+  # We want to add these no-pie flags to linking executables but not shared libraries:
+  LINKCC="$LINKCC -fno-pie -no-pie"
+  # Designate the DWARF version into 4 since the LLVM-BOLT does not support DWARF5 yet.
+  CFLAGS="$CFLAGS -gdwarf-4"
+  LDFLAGS="$LDFLAGS -gdwarf-4"
+  AC_SUBST(LLVM_BOLT)
+  AC_PATH_TOOL(LLVM_BOLT, llvm-bolt, '', ${llvm_path})
+  if test -n "${LLVM_BOLT}" -a -x "${LLVM_BOLT}"
+  then
+    AC_MSG_RESULT("Found llvm-bolt")
+  else
+    AC_MSG_ERROR([llvm-bolt is required for a --enable-bolt build but could not be found.])
+  fi
+
+  AC_SUBST(MERGE_FDATA)
+  AC_PATH_TOOL(MERGE_FDATA, merge-fdata, '', ${llvm_path})
+  if test -n "${MERGE_FDATA}" -a -x "${MERGE_FDATA}"
+  then
+    AC_MSG_RESULT("Found merge-fdata")
+  else
+    AC_MSG_ERROR([merge-fdata is required for a --enable-bolt build but could not be found.])
+  fi
+fi
+
 # Enable PGO flags.
 AC_SUBST(PGO_PROF_GEN_FLAG)
 AC_SUBST(PGO_PROF_USE_FLAG)