- [SerenityOS](https://github.com/SerenityOS/serenity) - supports decoding QOI system wide through a custom [cpp implementation in LibGfx](https://github.com/SerenityOS/serenity/blob/master/Userland/Libraries/LibGfx/QOILoader.h)
- [Raylib](https://github.com/raysan5/raylib) - supports decoding and encoding QOI textures through its [rtextures module](https://github.com/raysan5/raylib/blob/master/src/rtextures.c)
- [ImageMagick](https://github.com/ImageMagick/ImageMagick) - supports decoding and encoding QOI, since 7.1.0-20
- [ffmpeg](https://ffmpeg.org/) - supports decoding and encoding QOI since 5.1
- [darktable](https://github.com/darktable-org/darktable) - photography workflow application and raw developer, supports decoding since 4.4.0
- [KDE](https://kde.org) - supports decoding and encoding QOI images. Implemented in [KImageFormats](https://invent.kde.org/frameworks/kimagformats)