diff --git a/main/main.cpp b/main/main.cpp
index 92f40588f23e..fb42f71a75fb 100644
--- a/main/main.cpp
+++ b/main/main.cpp
@@ -478,6 +478,14 @@ Error Main::setup(const char *execpath, int argc, char *argv[], bool p_second_ph
 
 	I = args.front();
 	while (I) {
+#ifdef OSX_ENABLED
+		// Ignore the process serial number argument passed by macOS Gatekeeper.
+		// Otherwise, Godot would try to open a non-existent project on the first start and abort.
+		if (I->get().begins_with("-psn_")) {
+			I = I->next();
+			continue;
+		}
+#endif
 
 		List<String>::Element *N = I->next();