diff --git a/doc/classes/EditorSettings.xml b/doc/classes/EditorSettings.xml
index fca87f6a56bb..9015a12b43e2 100644
--- a/doc/classes/EditorSettings.xml
+++ b/doc/classes/EditorSettings.xml
@@ -433,12 +433,24 @@
 			The size to use for port previews in the visual shader uniforms (toggled by clicking the "eye" icon next to an output). The value is defined in pixels at 100% zoom, and will scale with zoom automatically.
 		</member>
 		<member name="filesystem/directories/autoscan_project_path" type="String" setter="" getter="">
-			The folder where projects should be scanned for (recursively), in a way similar to the project manager's [b]Scan[/b]button. This can be set to the same value as [member filesystem/directories/default_project_path] for convenience.
+			The folder where projects should be scanned for (recursively), in a way similar to the project manager's [b]Scan[/b] button. This can be set to the same value as [member filesystem/directories/default_project_path] for convenience.
 			[b]Note:[/b] Setting this path to a folder with very large amounts of files/folders can slow down the project manager startup significantly. To keep the project manager quick to start up, it is recommended to set this value to a folder as "specific" as possible.
 		</member>
 		<member name="filesystem/directories/default_project_path" type="String" setter="" getter="">
 			The folder where new projects should be created by default when clicking the project manager's [b]New Project[/b] button. This can be set to the same value as [member filesystem/directories/autoscan_project_path] for convenience.
 		</member>
+		<member name="filesystem/external_programs/3d_model_editor" type="String" setter="" getter="">
+			The program that opens 3D model scene files when clicking "Open in External Program" option in Filesystem Dock. If not specified, the file will be opened in the system's default program.
+		</member>
+		<member name="filesystem/external_programs/audio_editor" type="String" setter="" getter="">
+			The program that opens audio files when clicking "Open in External Program" option in Filesystem Dock. If not specified, the file will be opened in the system's default program.
+		</member>
+		<member name="filesystem/external_programs/raster_image_editor" type="String" setter="" getter="">
+			The program that opens raster image files when clicking "Open in External Program" option in Filesystem Dock. If not specified, the file will be opened in the system's default program.
+		</member>
+		<member name="filesystem/external_programs/vector_image_editor" type="String" setter="" getter="">
+			The program that opens vector image files when clicking "Open in External Program" option in Filesystem Dock. If not specified, the file will be opened in the system's default program.
+		</member>
 		<member name="filesystem/file_dialog/display_mode" type="int" setter="" getter="">
 			The display mode to use in the editor's file dialogs.
 			- [b]Thumbnails[/b] takes more space, but displays dynamic resource thumbnails, making resources easier to preview without having to open them.
diff --git a/editor/editor_settings.cpp b/editor/editor_settings.cpp
index 8ca98e6f764f..4879790b74f4 100644
--- a/editor/editor_settings.cpp
+++ b/editor/editor_settings.cpp
@@ -473,6 +473,12 @@ void EditorSettings::_load_defaults(Ref<ConfigFile> p_extra_config) {
 
 	/* Filesystem */
 
+	// External Programs
+	EDITOR_SETTING(Variant::STRING, PROPERTY_HINT_GLOBAL_DIR, "filesystem/external_programs/raster_image_editor", "", "")
+	EDITOR_SETTING(Variant::STRING, PROPERTY_HINT_GLOBAL_DIR, "filesystem/external_programs/vector_image_editor", "", "")
+	EDITOR_SETTING(Variant::STRING, PROPERTY_HINT_GLOBAL_DIR, "filesystem/external_programs/audio_editor", "", "")
+	EDITOR_SETTING(Variant::STRING, PROPERTY_HINT_GLOBAL_DIR, "filesystem/external_programs/3d_model_editor", "", "")
+
 	// Directories
 	EDITOR_SETTING(Variant::STRING, PROPERTY_HINT_GLOBAL_DIR, "filesystem/directories/autoscan_project_path", "", "")
 	const String fs_dir_default_project_path = OS::get_singleton()->has_environment("HOME") ? OS::get_singleton()->get_environment("HOME") : OS::get_singleton()->get_system_dir(OS::SYSTEM_DIR_DOCUMENTS);
diff --git a/editor/filesystem_dock.cpp b/editor/filesystem_dock.cpp
index f1ea8e8e6551..f41792af7ffd 100644
--- a/editor/filesystem_dock.cpp
+++ b/editor/filesystem_dock.cpp
@@ -1819,6 +1819,43 @@ void FileSystemDock::_file_option(int p_option, const Vector<String> &p_selected
 			OS::get_singleton()->shell_open(String("file://") + dir);
 		} break;
 
+		case FILE_OPEN_EXTERNAL: {
+			String fpath = path;
+			if (path == "Favorites") {
+				fpath = p_selected[0];
+			}
+
+			String file = ProjectSettings::get_singleton()->globalize_path(fpath);
+
+			String resource_type = ResourceLoader::get_resource_type(fpath);
+			String external_program;
+
+			if (resource_type == "CompressedTexture2D" || resource_type == "Image") {
+				if (file.get_extension() == "svg" || file.get_extension() == "svgz") {
+					external_program = EDITOR_GET("filesystem/external_programs/vector_image_editor");
+				} else {
+					external_program = EDITOR_GET("filesystem/external_programs/raster_image_editor");
+				}
+			} else if (ClassDB::is_parent_class(resource_type, "AudioStream")) {
+				external_program = EDITOR_GET("filesystem/external_programs/audio_editor");
+			} else if (resource_type == "PackedScene") {
+				// Ignore non-model scenes.
+				if (file.get_extension() != "tscn" && file.get_extension() != "scn" && file.get_extension() != "res") {
+					external_program = EDITOR_GET("filesystem/external_programs/3d_model_editor");
+				}
+			} else if (ClassDB::is_parent_class(resource_type, "Script")) {
+				external_program = EDITOR_GET("text_editor/external/exec_path");
+			}
+
+			if (external_program.is_empty()) {
+				OS::get_singleton()->shell_open(file);
+			} else {
+				List<String> args;
+				args.push_back(file);
+				OS::get_singleton()->create_process(external_program, args);
+			}
+		} break;
+
 		case FILE_OPEN: {
 			// Open folders.
 			TreeItem *selected = tree->get_root();
@@ -2606,9 +2643,13 @@ void FileSystemDock::_file_and_folders_fill_popup(PopupMenu *p_popup, Vector<Str
 		}
 
 		String fpath = p_paths[0];
-		String item_text = fpath.ends_with("/") ? TTR("Open in File Manager") : TTR("Show in File Manager");
+		bool is_directory = fpath.ends_with("/");
+		String item_text = is_directory ? TTR("Open in File Manager") : TTR("Show in File Manager");
 		p_popup->add_icon_shortcut(get_theme_icon(SNAME("Filesystem"), SNAME("EditorIcons")), ED_GET_SHORTCUT("filesystem_dock/show_in_explorer"), FILE_SHOW_IN_EXPLORER);
 		p_popup->set_item_text(p_popup->get_item_index(FILE_SHOW_IN_EXPLORER), item_text);
+		if (!is_directory) {
+			p_popup->add_icon_item(get_theme_icon(SNAME("ExternalLink"), SNAME("EditorIcons")), TTR("Open in External Program"), FILE_OPEN_EXTERNAL);
+		}
 		path = fpath;
 	}
 }
@@ -2714,6 +2755,7 @@ void FileSystemDock::_file_list_empty_clicked(const Vector2 &p_pos, MouseButton
 	file_list_popup->add_icon_item(get_theme_icon(SNAME("TextFile"), SNAME("EditorIcons")), TTR("New TextFile..."), FILE_NEW_TEXTFILE);
 	file_list_popup->add_separator();
 	file_list_popup->add_icon_shortcut(get_theme_icon(SNAME("Filesystem"), SNAME("EditorIcons")), ED_GET_SHORTCUT("filesystem_dock/show_in_explorer"), FILE_SHOW_IN_EXPLORER);
+
 	file_list_popup->set_position(files->get_screen_position() + p_pos);
 	file_list_popup->reset_size();
 	file_list_popup->popup();
diff --git a/editor/filesystem_dock.h b/editor/filesystem_dock.h
index 2304d8f8ad25..3f12b7304387 100644
--- a/editor/filesystem_dock.h
+++ b/editor/filesystem_dock.h
@@ -94,6 +94,7 @@ private:
 		FILE_NEW_SCRIPT,
 		FILE_NEW_SCENE,
 		FILE_SHOW_IN_EXPLORER,
+		FILE_OPEN_EXTERNAL,
 		FILE_COPY_PATH,
 		FILE_COPY_UID,
 		FILE_NEW_RESOURCE,